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UnknownPhase NA

Therapeutic Effects and Effects on Body Fat of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes for 1-4 Years

Assets

Dulaglutide / Semaglutide / Tirzepatide

Listed sites

1

Recruiting sites

1

Enrollment

100

estimated

Study population

Obesity / overweight, Type 2 diabetes

Key I/E criteria

BMI ≥24HbA1c ≥7.5%

Primary endpoint

Effects of different GLP-1 on blood glucose

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT05990374
Org study IDKY20220825-04

Timeline

Milestones

Study start2023-08-01estimated
Study first posted2023-08-14actual
Last update posted2023-08-14actual
Primary completion2024-01-01estimated
Study completion2024-01-01estimated

Assets

Investigational agents

Study populations

Who this study enrolls

Obesity / overweightType 2 diabetes

Eligibility

Who can enroll

SexAll
Healthy volunteersNot accepted

Inclusion criteria

1. Diagnosed type 2 diabetes according to the 1999 WHO standards;

2. received at least 8 weeks of simple diet control and physical exercise before screening; Patients with type 2 diabetes who were treated with stable hypoglycemic drugs and had inadequate glycemic control within 8 weeks prior to screening;

3. HbA1c≥7.5%;

4. BMI>24kg/m2;

5. Subjects agree to maintain a scientific diet and exercise habits throughout the study, and regularly self-monitor and record blood sugar (SMBG);

6. Be willing to sign written informed consent and comply with the study protocol

Exclusion criteria

1. Use of any of the following drugs or treatments in the 3 months prior to screening: treatment with GLP-1RA, GLP-1 analogue, DPP-4 inhibitor, or any other incretin analogue;

2. Long-term (more than 7 consecutive days) intravenous administration, oral administration, or intra-articular administration of corticosteroids within 2 months prior to screening;

3. Use of weight control drugs or surgery that can lead to weight instability within 2 months before screening, or are currently in a weight loss program and not in the maintenance stage:

4. History of acute and chronic pancreatitis; A history of medullary C-cell carcinoma, MEN (multiple endocrine tumors) 2A or 2B syndrome, or related family history;

5. Clinically significant gastric emptying abnormalities;

6. tumors of any organ system that have been treated or not treated in the 5 years prior to screening;

7. had received coronary angioplasty, coronary stenting, or coronary artery bypass within 6 months before screening. Negligent compensatory heart failure (NYHA rating III and IV), stroke or transient ischemic attack, unstable angina, myocardial infarction, persistent and clinically significant arrhythmia;

8. Acute metabolic complications occurred within 6 months before screening;

9. Before screening, any of the laboratory test indicators meet the following criteria: glutamic-pyrugenic transaminase >2.5 times or ASpartate transaminase >2.5 times; eGFR <45ml/min/1.73m2; Fasting glycerin tricol >5.64mmol/L.

Endpoints (2)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Coverage by outcome category

Weight & body composition
1
Glycemic / diabetes
1

Weight & body composition

1 endpoint
Secondary/protocol endpoint

Effects of different GLP-1 on body fat mass

Time frame:1,2,3,4 year

Total fat mass

change from baseline, improvement

Glycemic / diabetes

1 endpoint
Primary/protocol endpoint/low confidence

Effects of different GLP-1 on blood glucose

Time frame:1,2,3,4 year

change from baseline, improvement

Publications (1)

Bibliography

Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.

Registry references + supporting bibliography

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 1, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.