DelfaGLP-1 Atlas

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NPO-OOPS-TKR

Not yet recruitingPhase EARLY_1

Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist

Novel Perioperative Optimization of Obese Osteoarthritic Patients Pending Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist (NPO-OOPS-TKR)

Assets

GLP-1 / incretin class catch-all / Semaglutide

Listed sites

0

Recruiting sites

—

Enrollment

54

estimated

Study population

Obesity / overweight, Osteoarthritis

Key I/E criterion

•BMI ≥27

Primary endpoint

•Pain

Identifiers

Registered as

NCT IDNCT06807970
Org study IDUW24-423

Timeline

Milestones

Study first posted2025-02-04actual
Study start2025-09-01estimated
Last update posted2025-09-03actual
Primary completion2027-07-01estimated
Study completion2028-07-01estimated

Assets

Investigational agents

GLP-1 / incretin class catch-allSemaglutide

Study populations

Who this study enrolls

Obesity / overweightOsteoarthritis

Eligibility

Who can enroll

Minimum age40 Years
Maximum age80 Years
SexAll
Healthy volunteersNot accepted

Inclusion criteria

•Age between 40 and 80 years old
•BMI ≥27 kg/m2
•On the surgical waiting list for primary TKR
•Willing and able to cooperate in a weight management programme.
•Meeting indication for semaglutide

Exclusion criteria

•Revision surgery or surgery for neoplastic disease
•A medical condition which in the opinion of the investigators makes the patient unsuitable for participation in the trial
•Contraindication to GLP-1RA, like history of pancreatitis, severe gastrointestinal diseases such as gastroparesis, thyroid cancer, and inflammatory bowel disease
•Lack of acceptance of the randomisation process.

Endpoints (10)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Coverage by outcome category

Other clinical outcomes
5
Weight & body composition
3
Cardiometabolic biomarkers
1
Other (unclassified)
1

Weight & body composition

3 endpoints
Secondary/protocol endpoint

Body weight

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

Body weight, absolute change (kg)

change from baseline, improvement

Secondary/protocol endpoint

height

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

descriptive

Secondary/protocol endpoint

waist circumference

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

Waist circumference, change

change from baseline, improvement

Cardiometabolic biomarkers

1 endpoint
Secondary/protocol endpoint

blood pressure

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

descriptive, improvement

Other clinical outcomes

5 endpoints
Primary/protocol endpoint

Pain

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

change from baseline, improvement

Secondary/protocol endpoint

Length of stay

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

descriptive

Secondary/protocol endpoint

Radiological parameters

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

change from baseline, descriptive

Secondary/protocol endpoint

Western Ontario and McMaster Universities Arthritis Index (WOMAC)

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

descriptive, improvement

Secondary/protocol endpoint

The Knee Society Score

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

descriptive, improvement

Other (unclassified)

1 endpoint
Secondary/protocol endpoint/low confidence

A composite score of clinical situation

Time frame:As part of the standard of care when undergoing TKR, patients are routinely assessed at enrolment, 1 month and same day before surgery, and at 6 weeks,3 months, 6 months and 12 months post-surgery.

descriptive

componentsfailed same day rehabilitation, peri operative complications medical or surgical, post operative complications delayed discharge, wound complications, joint complications

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 1, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.