1. Age between 18 years (minimum age) and 50 years (maximum age), inclusive

2. Gender: Male or female, with a ratio of male to female being 2:1;

3. Body Mass Index (BMI) ≥28 kg/m²;

4. No prior use of semaglutide injection or antidiabetic medications;

5. Free Thyroxine (FT4) levels within normal range at screening;

6. Testosterone levels within normal range at screening (males only);

7. No plans for pregnancy from the time of signing the ICF until 2 months after the study ends, willingness to take effective contraceptive measures to prevent pregnancy or causing a partner's pregnancy, and no plans for sperm or egg donation during the study period;

8. Participants must voluntarily agree to and be able to comply with all scheduled visits, treatment plans, laboratory tests, special examinations, neurological assessments, and other trial procedures, and sign a written informed consent form.

1. Unable to accept regular follow-up;

2. Those who have difficulty with self-injection;

3. Weight change >5.0% in the 12 weeks prior to screening (self-reported);

4. History of allergic reactions to the study drug or similar drugs;

5. Evaluated by the investigator as unable to tolerate subcutaneous injection, such as those undergoing anticoagulant therapy, thrombocytopenia, known bleeding disorders, or idiopathic thrombocytopenic purpura;

6. Planning surgery within 1 year; history of gastrointestinal surgery (excluding polypectomy and appendectomy);

7. Positive blood HCG during screening; breastfeeding women; postmenopausal women; women with FSH >30 IU/L during screening;

8. Any of the following: myocardial infarction, stroke, unstable angina requiring hospitalization, or transient ischemic attack within 180 days before screening, classified as NYHA class III or higher;

9. Clinically significant severe ECG abnormalities (e.g., QT prolongation [>450 ms in men, >470 ms in women], ventricular Flutter, ventricular fibrillation, torsades de pointes, sick sinus syndrome, third-degree heart block without pacemaker therapy, and other severe abnormalities as assessed by the investigator), uncontrolled blood pressure despite treatment/untreated (systolic BP ≥160 mmHg and/or diastolic BP ≥100 mmHg during screening, systolic BP <90 mmHg and/or diastolic BP <50 mmHg), or other cardiovascular diseases deemed unsuitable for the study by the investigator;

10. Triglycerides ≥500 mg/dL (5.65 mmol/L);

11. Current or past history of malignancy, or currently having nodules with malignant potential such as thyroid nodules with TIRADS grade ≥4;

12. Tumor markers during screening: CA125 (for women), CA199, CEA, AFP above upper limit of normal range; PSA above upper limit of normal range (for men);

13. Hemoglobin A1c ≥6.5% during screening;

14. History of diabetes (type 1, type 2, special types, or gestational diabetes) or currently using injectable or oral antidiabetic medications;

15. Current or past history of acromegaly;

16. Proliferative or severe non-proliferative diabetic retinopathy at screening; fundus examination within 90 days before randomization: proliferative retinopathy or macular edema requiring acute treatment;

17. Used growth hormone therapy in the past 6 months;

18. Used any weight loss medications in the past 3 months; previously underwent obesity surgery or planned obesity surgery during the study;

19. Any of the following laboratory tests at screening: AST or ALT >2.5 ULN; total bilirubin >1.5 ULN; TSH <0.4 or >6 mIU/L; calcitonin >50 ng/L;

20. IGF-1 SDS >2.0 (age and gender matched);

21. Serum creatinine >1.5 ULN, eGFR <60 mL/min/1.73 m² [using the modified simplified MDRD equation: eGFR = 175 × (serum creatinine in mg/dL)^-1.234 × age^-0.179 × 0.79 for women], or kidney impairment requiring dialysis;

22. History of pancreatitis, or current acute or chronic pancreatitis;

23. History of cholecystitis, or current gallbladder/biliary disease symptoms, or treatable gallstones or polyps;

24. Family or personal history of multiple endocrine neoplasia type 2 or thyroid cancer (family defined as first-degree relatives);

25. Prior history of pituitary mass;

26. History of seizures;

27. Participated in another clinical trial with approved or investigational drugs/devices within 90 days before screening (excluding those who only signed the consent without receiving any intervention);

28. History of substance abuse and/or alcoholism, or mental disorders; during screening, had impaired consciousness including somnolence, stupor, coma, confusion;

29. Questionnaire PHQ-9 score ≥15; history of suicidal behavior; Columbia-Suicide Severity Rating Scale (C-SSRS) question 1 or 2 indicating suicidal ideation (answering "yes" to question 1 or 2);

30. Other reasons for exclusion as deemed by the investigator, such as any situation endangering participant safety or affecting compliance with the protocol.