← Trials/Trial dossier/NCT07362030

Active not recruitingPhase 1

Drug-durg Interaction of RAY1225 With Warfarin, Atorvastatin, Metformin and Digoxin

A Open-Label, Phase I Drug-drug Interaction Clinical Study to Investigate the Pharmacokinetics of RAY1225 With Warfarin, Atorvastatin, Metformin and Digoxin in Healthy Participants

Asset

RAY1225

Subcutaneous · GLP-1 / GIP dual

Listed sites

1

Recruiting sites

Enrollment

32

actual

Study population

Healthy volunteers

Key I/E criterion

BMI 20-35

Primary endpoints

CmaxArea under the curve(AUC)

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT07362030
Org study IDRAY1225-24-11

Timeline

Milestones

Study start2025-04-14actual
Primary completion2025-12-27actual
Study first posted2026-01-23actual
Last update posted2026-01-23actual
Study completion2026-03-30estimated

Assets

Investigational agents

Study populations

Who this study enrolls

Healthy volunteers

Eligibility

Who can enroll

Minimum age18 Years
Maximum age55 Years
SexAll
Healthy volunteersAccepted

Inclusion criteria

1. Body mass index (BMI) ≥20 to ≤35 kg/m2 and total body weight >50 kg(male) or >45kg(female) at Screening (calculated as a function of measured height and weight according to the formula, BMI = kg / m2 where m2 is height in meters squared);

2. Ability to understand and willingness to sign a written informed consent form;

3. Normal physical examination, vital signs, 12-lead ECG, and clinical laboratory values, or any abnormality that is non-clinically significant.

Exclusion criteria

1. Participants with a history of hypersensitivity to study drug or any component of study medication;

2. Participants had taken prescription, over-the-counter, herbal, or vitamin products within 4 weeks prior to screening;

3. Smoking more than 5 cigarettes per day within 12 weeks prior to screening,or who cannot stop using any tobacco products during the study period;

4. Participants who donated blood/bleeding profusely (> 400 mL) 12 weeks prior to randomization;

5. Those with clinically significant Electrocardiogram(ECG) abnormalities, or QTcF > 450ms;

6. Participants who test positive at Screening and/or admission (Day -1) for alcohol abuse.

7. Females who are pregnant, lactating, or likely to become pregnant during the study.

8. History of dysphagia or any gastrointestinal disorder that affect absorption

Endpoints (3)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Safety / tolerability / PK

3 endpoints
Primary/protocol endpoint

Pharmacokinetic - Cmax

Time frame:Day 1~Day 5 and Day 86~Day 107

concentration, descriptive

Primary/protocol endpoint

Pharmacokinetic -Area under the curve(AUC)

Time frame:Day 1~Day 5 and Day 86~Day 107

concentration, descriptive

Secondary/protocol endpoint

Number of participants with adverse events

Time frame:DAY 1~Day 107

event count, event

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 1, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.