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Drug-durg Interaction of RAY1225 With Warfarin, Atorvastatin, Metformin and Digoxin
A Open-Label, Phase I Drug-drug Interaction Clinical Study to Investigate the Pharmacokinetics of RAY1225 With Warfarin, Atorvastatin, Metformin and Digoxin in Healthy Participants
Lead sponsor
Asset
RAY1225
Subcutaneous · GLP-1 / GIP dual
Listed sites
1
Recruiting sites
—
Enrollment
32
actual
Study population
Healthy volunteers
Key I/E criterion
•BMI 20-35
Primary endpoints
•Cmax•Area under the curve(AUC)
Footprint
Where this trial recruits
Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.
Identifiers
Registered as
Timeline
Milestones
Assets
Investigational agents
Study populations
Who this study enrolls
Eligibility
Who can enroll
Inclusion criteria
1. Body mass index (BMI) ≥20 to ≤35 kg/m2 and total body weight >50 kg(male) or >45kg(female) at Screening (calculated as a function of measured height and weight according to the formula, BMI = kg / m2 where m2 is height in meters squared);
2. Ability to understand and willingness to sign a written informed consent form;
3. Normal physical examination, vital signs, 12-lead ECG, and clinical laboratory values, or any abnormality that is non-clinically significant.
Exclusion criteria
1. Participants with a history of hypersensitivity to study drug or any component of study medication;
2. Participants had taken prescription, over-the-counter, herbal, or vitamin products within 4 weeks prior to screening;
3. Smoking more than 5 cigarettes per day within 12 weeks prior to screening,or who cannot stop using any tobacco products during the study period;
4. Participants who donated blood/bleeding profusely (> 400 mL) 12 weeks prior to randomization;
5. Those with clinically significant Electrocardiogram(ECG) abnormalities, or QTcF > 450ms;
6. Participants who test positive at Screening and/or admission (Day -1) for alcohol abuse.
7. Females who are pregnant, lactating, or likely to become pregnant during the study.
8. History of dysphagia or any gastrointestinal disorder that affect absorption
Endpoints (3)
What's being measured
Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.
Safety / tolerability / PK
3 endpointsPharmacokinetic - Cmax
Time frame:Day 1~Day 5 and Day 86~Day 107
concentration, descriptive
Pharmacokinetic -Area under the curve(AUC)
Time frame:Day 1~Day 5 and Day 86~Day 107
concentration, descriptive
Number of participants with adverse events
Time frame:DAY 1~Day 107
event count, event
Provenance
Sources
Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.