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Not yet recruitingPhase 1

A Mass Balance Study Of 14C-RAY1225 Injection In Healthy Chinese Participants

A Mass Balance Study of 14C-RAY1225 Injection in Healthy Chinese Participants

Asset

RAY1225

Subcutaneous · GLP-1 / GIP dual

Listed sites

1

Recruiting sites

Enrollment

8

estimated

Study population

Healthy volunteers

Key I/E criteria

BMI 20-35Healthy volunteers

Primary endpoints

Total radioactivity recovery and cumulative recovery in urineRadioactivity of each metabolite in urine

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT07460284
Org study IDRAY1225-25-16

Timeline

Milestones

Study first posted2026-03-10actual
Last update posted2026-03-10actual
Study start2026-03-15estimated
Primary completion2026-10-14estimated
Study completion2026-10-28estimated

Assets

Investigational agents

Study populations

Who this study enrolls

Healthy volunteers

Eligibility

Who can enroll

Minimum age18 Years
Maximum age55 Years
SexAll
Healthy volunteersAccepted

Inclusion criteria

1. Participants who sign the informed consent form, fully understand the content, process, and possible adverse reactions of the study, and are able to complete the study as required by the study protocol;

2. Healthy adult males aged 18-55 years (inclusive, based on the time of signing the ICF);

3. Weight ≥ 50 kg, and body mass index (BMI) = weight (kg)/height2 (m 2) between 20.0-35.0 kg/m2 (inclusive);

4. Participants (including partners) who agree to voluntarily use effective contraception from screening until 6 months after the investigational drug administration and have no sperm donation plan. For specific contraceptive measures

Exclusion criteria

1. Subjects with trauma, surgical scar, or skin lesions at the proposed administration site (abdomen) who are not suitable for subcutaneous injection as assessed by the investigator;

2. History of hypoglycemic episodes within 12 months prior to screening;

3. Major surgery or serious infection within 12 weeks prior to screening;

4. Acute disease from the signing of the ICF to the administration of the investigational drug;

5. Smoking more than 5 cigarettes per day within 12 weeks prior to screening, or unable to abstain from smoking within 7 days prior to admission and during the study;

6. Participants who are not otherwise eligible to participate in this study.

Endpoints (3)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Safety / tolerability / PK

3 endpoints
Primary/protocol endpoint

Total radioactivity recovery and cumulative recovery in urine and feces in each time period;

Time frame:DAY1~DAY60

descriptive

Primary/protocol endpoint

Radioactivity of each metabolite in urine and feces as a percentage of the total administered dose and the circulating metabolites in plasma as a percentage of the total exposure AUC (%AUC);

Time frame:DAY1~DAY60

concentration, descriptive

Secondary/protocol endpoint

Occurrence of adverse events/significant adverse events/serious adverse events

Time frame:DAY1~DAY60

descriptive

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 1, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.