DelfaGLP-1 Atlas

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CompletedPhase NA

Effect of Lower Doses of Colonic Nutrient Supplementation on Appetite Hormones and Food Intake in Obese Adults

The Effect of Nutrients on Regulating Appetite - a Dosing Study

Asset

GLP-1 / incretin class catch-all

Oral

Listed sites

1

Recruiting sites

—

Enrollment

16

actual

Study population

Obesity / overweight

Key I/E criterion

•BMI 30-40

Primary endpoint

•Circulating levels of appetite-regulating gut hormones (PYY, GLP-1, ghrelin)

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT07491835
Org study IDQME23.0015
Secondary ID123456Innovate UK

Timeline

Milestones

Study start2023-10-18actual
Primary completion2023-11-11actual
Study completion2023-11-11actual
Study first posted2026-03-25actual
Last update posted2026-03-25actual

Assets

Investigational agents

GLP-1 / incretin class catch-all

Study populations

Who this study enrolls

Obesity / overweight

Eligibility

Who can enroll

Minimum age18 Years
Maximum age60 Years
SexAll
Healthy volunteersNot accepted

Inclusion criteria

•Aged 18 years or over
•BMI 30-40 kg/m²
•No prior bowel surgery
•Not taking medications for Type II diabetes
•Willing to consume standardised test meals
•Able to understand the study information sheet and instructions in English
•Able to provide written informed consent

Exclusion criteria

•BMI outside the range of 30-40 kg/m²
•Major gut surgery involving removal of any part of the gastrointestinal tract
•Known major bowel disease
•Currently taking medication for Type 1 or Type 2 diabetes
•Currently taking medication for weight loss (e.g., semaglutide)
•Unable to understand English or provide informed consent

Endpoints (3)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Coverage by outcome category

Other (unclassified)
2
Patient-reported / QoL
1

Patient-reported / QoL

1 endpoint
Secondary/protocol endpoint

Subjective hunger and appetite ratings using visual analogue scales (VAS)

Time frame:30 minutes from 08:00 to 16:00 on the study visit day (17 time points)

descriptive, improvement

Other (unclassified)

2 endpoints
Primary/protocol endpoint/low confidence

Change in circulating levels of appetite-regulating gut hormones (PYY, GLP-1, ghrelin)

Time frame:Baseline and every 30 minutes up to 8 hours on the study visit day for each dose group

concentration, descriptive

Secondary/protocol endpoint/low confidence

Total caloric intake

Time frame:Measured at breakfast and lunch on the study visit day for each dose group

descriptive

Publications (1)

Bibliography

Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.

Registry references + supporting bibliography

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 1, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.