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Insulin

8 trials in this asset. Source: ClinicalTrials.gov, as of July 21, 2026.

Trials

8

Ongoing

1

Recruiting

1

Completed

4

Sites

31

Countries

2

Endpoints

125

Composite endpoints

0

Distinct sites and countries across this asset's trials. A site running several of its trials counts once, matching the map. All 125 linked ClinicalTrials.gov endpoints are classified into the categories below. Trial and endpoint linkage does not by itself establish treatment attribution for every endpoint.

Development

Where the program stands

Trials by phase

Phase 2
6
Phase 2/3
1
Not applicable
1

Trials by status

Recruiting
1
Completed
4
Terminated
1
Withdrawn
2

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Other (unclassified)
26
Global cognition
16
Amyloid biomarkers
15
Memory
13
Neuroimaging
11
Other clinical outcomes
10
Fluid / digital biomarkers
8
Safety / tolerability / PK
6
Executive function / language
5
Behavior / neuropsychiatric
5
Function / daily living
4
Tau biomarkers
4
Neurodegeneration biomarkers
2

Most-measured metrics

Top 20 metrics across this asset's endpoints

Normalized metric codes are available for 21 of 125 classified ClinicalTrials.gov endpoints for this asset; the ranking below covers that coded subset.

ADAS-CogCognition

9

Clinical Dementia Rating-Sum of Boxes (CDR-SB)Cognition

4

Mini-Mental State Examination (MMSE)Cognition

3

ADCS-Activities of Daily Living (ADCS-ADL)Function

3

Phosphorylated tau 181 (p-tau181)Other

1

Neurofilament light (NfL)Neurodeg.

1

Trials

Trials for this asset

Every trial for this asset, with the same search, filters, and sort as the Trials tab.

8 of 8

Alzheimer’s disease and related dementias trials
Asset / Disease areaKey I/E criterionEvidence
NCT01767909The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)

Insulin

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseasePh 2/3Completed25Dec 20187results
SL120Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120)

Insulin, Insulin detemir

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseasePh 2Completed2Mar 2015-results
SNIFF 120SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days)

Insulin

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseasePh 2Completed1Dec 20114
NCT05081219SNIFF - Combo INI+EMPA Trial

Empagliflozin, Insulin

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseasePh 2Completed1Sep 202453results
NCT06072963COMMETS- Combination MCI Metabolic Syndrome

Insulin, Semaglutide

Alzheimer’s disease, MCI / preclinical Alzheimer’s

MoCA ≤27Ph 2Recruiting1Dec 202758
NCT04115384Intranasal Insulin in Frontotemporal Dementia (FTD)

Insulin

Frontotemporal dementia

MMSE ≥18Ph 2Terminated1Feb 2020-results
NCT05006599SNIFF - 3-Week Aptar CPS Device

Insulin

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseasePh 2Withdrawn0May 202952
Memori³Investigating Brain Insulin Resistance in Alzheimer Disease with IntraNasal Insulin : a Multimodal Neuroimaging Study

Insulin

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseaseNot applicableWithdrawn0Mar 202616

Showing 1-8 of 8 trials