Amisulpride Treatment for BPSD in AD Patients

1. It conforms to the diagnostic standard of Alzheimer's disease in International Classification of Diseases 10th Revision (ICD-10)

2. a total score of MMSE<24

3. The patients had active behavioral symptoms with a minimum score of 20 on the 12-point Neuropsychiatric Inventory (NPI)

4. Participant or guardian has to sign informed consent. The patients' guardians will sign the informed consent on behalf of the participants when the capacity of participants to consent is compromised

1. People with vascular dementia, frontotemporal dementia, dementia with Lewy bodies or other neurocognitive disorders;

2. Patients with severe brain organic diseases or brain trauma;

3. Physical illnesses associated with severe respiratory, circulatory, immune, and endocrine systems;

4. History of other mental disorders;

5. Those who are allergic to amisulpride or olanzapine;

6. Patients who are contraindicated with amisulpride and olanzapine: pheochromocytoma, prolactin-dependent tumors and narrow-angle glaucoma;