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Subcutaneous · GLP-1 agonist

Efpeglenatide

14 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

14

Active

2

Recruiting

1

Completed

6

Sites

461

Countries

31

Endpoints

94

Composite endpoints

14

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
2
Phase 2
4
Phase 2/3
1
Phase 3
7

Trials by status

Recruiting
1
Active, not recruiting
1
Completed
6
Terminated
4
Unknown
2

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Glycemic / diabetes
40
Weight & body composition
21
Safety / tolerability / PK
21
Cardiometabolic biomarkers
6
Cardiovascular outcomes
3
Renal / kidney
1
Patient-reported / QoL
1
Other (unclassified)
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

HbA1c, changeGlycemic

11

Body weight, absolute change (kg)Weight

9

Documented hypoglycemiaSafety/PK

9

Fasting glucose, changeGlycemic

8

HbA1c <7.0% achievementGlycemic

7

Treatment-emergent AEs (any)Safety/PK

5

Waist circumference, changeWeight

3

Immunogenicity (ADA)Safety/PK

2

3-point MACECV

2

BMI, changeWeight

2

Body weight, % changeWeight

2

≥5% weight-loss respondersWeight

2

HbA1c <6.5% achievementGlycemic

1

AUC₀–∞Safety/PK

1

5-point MACECV

1

Custom renal compositeRenal

1

≥10% weight-loss respondersWeight

1

IWQOL-Lite physicalPRO/QoL

1

Plasma concentration (steady state)Safety/PK

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

14 of 14

Asset / PopulationKey I/E criterionEvidence
AMPLITUDE-OEffect of Efpeglenatide on Cardiovascular Outcomes

Efpeglenatide

Cardiovascular disease, Type 2 diabetes

Ph 3Terminated353Dec 20205results
AMPLITUDE-MEfficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Diet and Exercise

Efpeglenatide

Type 2 diabetes

HbA1c 7-10%Ph 3Completed54Jan 20201results
AMPLITUDE-SEfficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Alone or in Combination With Sulfonylurea

Efpeglenatide

Type 2 diabetes

Ph 3Terminated48Nov 2020results
AMPLITUDE-LEfficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Basal Insulin Alone or in Combination With Oral Antidiabetic Drug(s)

Efpeglenatide

Type 2 diabetes

Ph 3Terminated47Nov 2020results
AMPLITUDE-DEfficacy and Safety of Efpeglenatide Versus Dulaglutide in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin

Dulaglutide, Efpeglenatide

Type 2 diabetes

Ph 3Terminated45Oct 2020results
AGREEThe Effects of Exenatide After Gastric Restriction

Efpeglenatide, Exenatide

Bariatric Surgery, Obesity / overweight

BMI ≥40Ph 2/3Unknown2Dec 2010
NCT02057172Glycaemic Control of Weekly LAPS-Exendin Versus Placebo in Subjects of Type 2 Diabetes

Efpeglenatide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Type 2 diabetes

HbA1c 7-10%Ph 2Completed1Oct 20141
NCT02075281Effect of LAPS-Exendin on Body Weight in Obese Population

Efpeglenatide, Exenatide

Obesity / overweight

Healthy volunteersPh 2Completed1Jan 2015
NCT07379333A Study to Evaluate Efficacy and Safety of HM11260C in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin and Dapagliflozin

Efpeglenatide

Type 2 diabetes

BMI ≤45Ph 3Recruiting1Nov 2027
NCT02059564A Phase 1b Study of LAPS-Exendin in Subjects of Type 2 Diabetes Mellitus

Efpeglenatide, Exenatide, Liraglutide

Type 2 diabetes

BMI 18-45Ph 1Unknown1Oct 20141
NCT06174779A Study to Evaluate Efficacy and Safety of HM11260C in Adult Obesity Patients Without Diabetes Mellitus

Efpeglenatide

Obesity / overweight

BMI ≥30Ph 3Active, not recruiting1Dec 2025
NCT02081118Glycaemic Control of Monthly LAPS-Exendin Versus Placebo in Subjects of Type 2 Diabetes

Efpeglenatide, Exenatide

Type 2 diabetes

HbA1c 7-10%Ph 2Completed1Mar 2015
NCT01452451Safety, Tolerability, Pharmacokinetics,Pharmacodynamics Study of LAPS-Exendin in Subjects of Type 2 Diabetes Mellitus

Efpeglenatide, Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

HbA1c 7-10%Ph 2Completed1Jun 2013
NCT01093729A Study of HM11260C in Healthy Male Subject

Efpeglenatide, Exenatide

Healthy volunteers

BMI 18-27Ph 1Completed0Oct 2010