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Oral · GLP-1 agonist

Ecnoglutide (VRB-101)

2 trials in this program. Source: ClinicalTrials.gov, as of July 6, 2026.

Distinct formulations of the same molecule

This molecule is developed in parallel as separate programs. They are not competing therapies (they share the same active drug) but differ by formulation, route, and developer. Trials below are labeled with their program code.

Trials

2

Ongoing

2

Recruiting

0

Completed

0

Sites

37

Countries

1

Endpoints

13

Composite endpoints

2

Distinct sites and countries across this program's trials. A site running several of its trials counts once, matching the map.

Where the program stands

Trials by phase

Phase 2
2

Trials by status

Not yet recruiting
1
Active, not recruiting
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Weight & body composition
6
Safety / tolerability / PK
4
Cardiometabolic biomarkers
2
Other (unclassified)
1

Top 20 metrics across this asset's endpoints

Body weight, % changeWeight

2

Body weight, absolute change (kg)Weight

2

Treatment-emergent AEs (any)Safety/PK

2

≥5% weight-loss respondersWeight

1

BMI, changeWeight

1

Trials for VRB-101

Every trial for this program, with the same search, filters, and sort as the Trials tab.

2 of 2

GLP-1 and incretin trials
Asset / PopulationEligibility highlightEvidence
EVOLVE-2A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Ecnoglutide (VRB-101)

Obesity / overweight

BMI 27-30Ph 2Active, not recruiting23Jul 2026-
NCT07553299A Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Ecnoglutide (VRB-101)

Obesity / overweight

BMI 27-30Ph 2Not yet recruiting17Nov 2026-

Showing 1-2 of 2 trials