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Delfa

← All trials/NCT01451905

UnknownPhase NA

GLP-1 Receptors in Normal Skin and Skin From Patients With Psoriasis

Assets

GLP-1 / incretin class catch-all / Liraglutide

Listed sites

1

Recruiting sites

1

Estimated enrollment

12

Study population

Obesity / overweight, Psoriasis / psoriatic arthritis

Eligibility highlights

•BMI ≥27

Primary endpoint

•Changes in PASI and DLQI

Registered trial locations

Locations reported to ClinicalTrials.gov for this trial snapshot. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT01451905
Org study IDGLP1-PSO

Timeline

Milestones

Study first posted2011-10-14estimated
Last update posted2012-06-21estimated
Study start2011-08 (month precision)
Primary completion2012-12estimated (month precision)
Study completion2012-12estimated (month precision)

Assets

Investigational agents

GLP-1 / incretin class catch-allLiraglutide

Who this study enrolls

Obesity / overweightPsoriasis / psoriatic arthritis

Who can enroll

Minimum age18 Years
SexAll
Healthy volunteersNot accepted

Eligibility criteria

4.3 Inclusion Criteria

•Caucasians above 18 years of age
•Plaque psoriasis
•PASI score >10
•No treatment or stable treatment of psoriasis during at least 3 months before inclusion
•Steady weight through 3 months with a body mass index (BMI) above 27 kg/m2
•Normal blood pressure
•Spiral or hormonal birth control for fertile women during the entire treatment period and at least 3 days after the end of the treatment period (~5 times the plasma half-life) 4.4 Exclusion Criteria
•Psoriasis arthritis
•Fasting plasma glucose > 7.5 mmol/L or HbA1c > 7.5%
•Type 1 diabetes
•Treatment for type 2 diabetes with GLP-1-based medicine (DDP-4-inhibitors or GLP-1-receptor-agonists)
•Heart failure, NYHA class III-IV
•Uraemia, end-stage renal disease, or any other cause of impaired renal function with s-creatinine >150 µM and/or albuminuria
•Liver disease (alanine amino transferase (ALAT) and/or aspartate amino transferase (ASAT) >2 x upper normal serum levels)
•Anaemia
•Acute or chronic pancreatitis
•Struma or thyroid cancer
•Pregnancy or breast feeding
•Inability to complete the study

Endpoints (1)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Other clinical outcomes

1 endpoint
Primary/protocol endpoint/low confidence

Changes in PASI and DLQI

Time frame:2 months

change from baseline, improvement

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 6, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 6, 2026 snapshot.