Study of Effectiveness of Liraglutide Added to High Dose Insulin in Type II Diabetics

1. Male and female patients with Type 2 diabetes with HbA1c from 6.5 to 10% treated with intensive insulin therapy (MDI or CSII, including U-500 insulin-treated patients) using > 100 units of insulin, with or without a stable dose of oral insulin sensitizing medications, for at least three months.

2. Aged 18 to 80 years.

3. Females of child-bearing potential must be using adequate form of contraception.

4. Patient willing to monitor BG four times daily, use CGM, and comply with study-related protocol.

1. Type 1 diabetes.

2. Use of any GLP-1 receptor agonist within previous three months.

3. Use of DPP-4 inhibitors or oral insulin secretagogues within the previous three months.

4. Use of glucocorticoids (except inhaled).

5. Use of any experimental drug within previous three months.

6. Known or suspected allergy to liraglutide, Novolog or Levemir.

7. Personal or family history of medullary carcinoma of the thyroid or MEN-2.

8. Concomitant chronic renal disease with creatinine > 1.5%.

9. Concomitant chronic hepatic, gastrointestinal or other illness (including pancreatitis or active cardiovascular disease except stable exertional angina).

10. Inability or unwillingness to monitor BG, use CGM, or comply with study protocol.

11. Women of child-bearing potential unwilling to use adequate contraception, intending to become pregnant or breast-feeding.