Closedloop

1. Age greater than 18 years and less than 30 years.

2. Have had diabetes for at least 1 year, and in good control (HbA1C less than 8.5 %).

3. Be on continuous subcutaneous insulin infusion using an insulin pump

4. Subjects must be otherwise healthy except for T1DM, and treated for hypothyroidism if present

5. Menstruating women must have negative pregnancy test.

6. Hemoglobin (Hb) more than 12 g/dl

7. Weight must be equal to or greater than 50 Kg

1. Any chronic disease (leukemia, asthma, inflammatory bowel disease, cystic fibrosis, juvenile rheumatoid arthritis, etc that directly, or as a result of treatment, directly or indirectly affect glucose homeostasis).

2. Hemoglobin less than 12 g/dl

3. Lack of a supportive family environment

4. Positive pregnancy test based on serum beta HCG in menstruating young women

5. Evidence or history of chemical abuse

6. HbA1c more than 8.5 %

7. Weight less than 50 Kg

8. History of gastroparesis and on medications that alter gastric emptying

9. History of Pancreatitis and impaired renal function

10. Hypoglycemic unawareness

11. History of sensitivity to 5-HT3 receptor antagonists

12. History of QT prolongation

13. Concomitant use of both Acetaminophen and vitamin C

14. Patients on glucocorticoid therapy

15. Known allergies to any of the study medication