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Intravenous / Subcutaneous · GLP-1 agonist

Exenatide

384 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

384

Active

19

Recruiting

10

Completed

279

Sites

3,304

Countries

60

Endpoints

3,029

Composite endpoints

141

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Early Phase 1
5
Phase 1
48
Phase 1/2
14
Phase 2
52
Phase 2/3
9
Phase 3
84
Phase 4
88
Not applicable
84

Trials by status

Not yet recruiting
1
By invitation
1
Recruiting
10
Active, not recruiting
7
Completed
279
Terminated
24
Withdrawn
12
Unknown
50

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Glycemic / diabetes
875
Safety / tolerability / PK
544
Cardiometabolic biomarkers
445
Weight & body composition
287
Other clinical outcomes
285
Other (unclassified)
263
Patient-reported / QoL
129
Cardiovascular outcomes
89
Renal / kidney
57
MASH / liver
30
Heart failure
25

Most-measured metrics

Top 20 metrics across this asset's endpoints

HbA1c, changeGlycemic

179

Body weight, absolute change (kg)Weight

127

Fasting glucose, changeGlycemic

99

Postprandial glucoseGlycemic

97

Documented hypoglycemiaSafety/PK

88

HbA1c <7.0% achievementGlycemic

69

Treatment-emergent AEs (any)Safety/PK

67

Triglycerides, changeBiomarker

48

BMI, changeWeight

42

HOMA-IR (insulin sensitivity)Glycemic

40

Total cholesterol, changeBiomarker

39

HbA1c <6.5% achievementGlycemic

36

AUC₀–∞Safety/PK

35

HDL-C, changeBiomarker

34

Systolic BP, changeBiomarker

32

Plasma concentration (steady state)Safety/PK

28

Heart rate, changeBiomarker

26

Waist circumference, changeWeight

23

LDL-C, changeBiomarker

22

CmaxSafety/PK

21

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

384 of 384

Asset / PopulationKey I/E criterionEvidence
NCT01144338Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

HbA1c 6.5-10%Ph 3Completed629Apr 201718results
NCT01789957Extension Study for 2993-112

Exenatide

Type 2 diabetes

Ph 3Completed226Jun 2004
NCT00717457A Study of Taspoglutide Versus Exenatide for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin, Thiazolidinedione or a Combination of Both.

Exenatide, Taspoglutide

Type 2 diabetes

BMI ≥25Ph 3Completed216Mar 20111
NCT00518115Out-Patient Study in Patients With Type 2 Diabetes Mellitus Who Are Taking no Diabetes Medication or Metformin Only

Albiglutide, Exenatide

Type 2 diabetes

BMI 20-40Ph 2Completed163May 20082results
SUSTAIN™ 3Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes

Exenatide, Semaglutide

Type 2 diabetes

HbA1c 7-10.5%Ph 3Completed146Jul 201518results
NCT02229396Phase 3 28-Week Study With 24-Week and 52-week Extension Phases to Evaluate Efficacy and Safety of Exenatide Once Weekly and Dapagliflozin Versus Exenatide and Dapagliflozin Matching Placebo

Exenatide

Type 2 diabetes

HbA1c 8-12%Ph 3Completed133Apr 20164results
NCT00039013Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With Metformin

Exenatide

Type 2 diabetes

BMI 27-45Ph 3Completed129Jun 20034
NCT00039026Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With a Sulfonylurea

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 27-45Ph 3Completed126Aug 20033
LEAD-6Effect of Liraglutide or Exenatide Added to an Ongoing Treatment on Blood Glucose Control in Subjects With Type 2 Diabetes

Exenatide, Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Completed125Apr 200816results
LixiLan-GEfficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FRC Extension Period

Albiglutide, Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Lixisenatide

Type 2 diabetes

Ph 3Completed124May 20185results
NCT02229383Phase III Study to Evaluate Safety and Efficacy of Added Exenatide Versus Placebo to Titrated Basal Insulin Glargine in Inadequately Controlled Patients With Type II Diabetes Mellitus

Exenatide

Type 2 diabetes

HbA1c 7.5-12%Ph 3Completed123Aug 20162results
NCT01455857A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

HbA1c 7.5-10%Ph 3Completed121Aug 20141
NCT00359762Exenatide Versus Glimepiride in Patients With Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 3Completed114Mar 20113results
DUAL™ IIIThe Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD Therapy

Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Type 2 diabetes

BMI ≤40Ph 3Completed109Mar 20143results
NCT01029886Safety and Efficacy of Exenatide Once Weekly Versus Liraglutide in Subjects With Type 2 Diabetes

Exenatide, Liraglutide

Type 2 diabetes

BMI ≤45Ph 3Completed108Jan 20112results
NCT00676338Safety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4)

Exenatide

Type 2 diabetes

BMI 23-45Ph 3Completed106Jul 20105results
NCT03060980Comparison of Efficacy, Safety, and Tolerability of ITCA 650 to Empagliflozin and Glimepiride as add-on Metformin

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-45Ph 3Terminated101Jan 2018
NCT00035984Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 27-45Ph 3Completed100Aug 20033
NCT00635492CHOICE: CHanges to Treatment and Outcomes in Patients With Type 2 Diabetes Initiating InjeCtablE Therapy

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

Completed96Dec 20112results
NCT00960661A Trial Comparing Two Therapies: Basal Insulin/Glargine, Exenatide and Metformin Therapy (BET) or Basal Insulin/Glargine, Bolus Insulin Lispro and Metformin Therapy (BBT) in Subjects With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed95Aug 20121results
NCT00082381Effect of AC2993 Compared With Insulin Glargine in Patients With Type 2 Diabetes Also Using Combination Therapy With Sulfonylurea and Metformin

Exenatide

Type 2 diabetes

HbA1c 7-10%Ph 3Completed91Jul 20083results
AWARD-1A Study in Participants With Type 2 Diabetes Mellitus

Dulaglutide, Exenatide

Type 2 diabetes

BMI 23-45Ph 3Completed89Nov 20113results
NCT00641056Efficacy of Exenatide Once Weekly and Once-Daily Insulin Glargine in Patients With Type 2 Diabetes Treated With Metformin Alone or in Combination With Sulfonylurea (DURATION - 3)

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed75May 20097results
NCT00082407Exenatide Compared With Twice-Daily Biphasic Insulin Aspart in Patients With Type 2 Diabetes Using Sulfonylurea and Metformin

Exenatide

Type 2 diabetes

BMI 25-40Ph 3Completed69Jul 20083results
NCT00637273A Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION - 2)

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed62Feb 20098results
NCT04154072A Clinical Study of NLY01 in Patient's With Early Parkinson's Disease

Exenatide

Parkinson's disease

Ph 2Completed61Feb 20231
NCT00111540Study to Examine the Effect on Glucose Control and Safety/Tolerability of Exenatide Given Two Times a Day to Subjects With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed60Sep 20065
DURATION-NEO-2Comparison Study of the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly Suspension to Sitagliptin and Placebo in Subjects With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI ≤45Ph 3Completed60Apr 20142results
NCT00765817Addition Of Exenatide To Insulin Glargine In Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI ≤45Ph 3Completed59Jan 20105results
DURATION-NEO-1Efficacy and Safety of Exenatide Once Weekly Suspension in Subjects With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI ≤45Ph 3Completed58Aug 20142results
NCT01455870A Study to Evaluate ITCA 650 Compared to Sitagliptin as add-on Therapy for the Treatment of Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 7.5-10.5%Ph 3Completed54Jul 2015
NCT00658021Safety and Efficacy of Exenatide as Monotherapy and Adjunctive Therapy to Oral Antidiabetic Agents in Adolescents With Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 6.5-10.5%Ph 3Completed53Apr 2019results
NCT00560417Comparison of Two Basal Insulins for Patients With Type 2 Diabetes Taking Oral Diabetes Medicines and Exenatide

Exenatide

Type 2 diabetes

HbA1c ≥7%Ph 3Completed52Dec 2009results
NCT00099320Safety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Thiazolidinediones or Thiazolidinediones and Metformin

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed51Aug 20052
NCT01785771A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes in Patients With High Baseline HbA1c

Exenatide

Type 2 diabetes

HbA1c 10-12%Ph 3Terminated51Jan 20181
NCT02119819A Study to Compare a New Drug for Type 2 Diabetes to Placebo and to a Treatment Already Available for Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 23-45Ph 2Completed51Aug 20151results
NCT00943917Study of ITCA 650 (Exenatide in DUROS) in Subjects With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

HbA1c 7-10%Ph 2Completed50Aug 20101results
NCT01060059Exenatide and Basal Insulins Use in the Real Setting: an Observational Study in Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c ≥7%Completed50May 2012results
NCT01940770Specific Clinical Experience Investigation for Long-term Use of Bydureon.

Exenatide

Type 2 diabetes

Completed47Nov 2019
NCT01817569Specific Clinical Experience Investigation for Long-term Use of Exenatide (Byetta Subcutaneous Injection)

Exenatide

Type 2 diabetes

Completed46Oct 2019
NCT00917267A Study to Examine the Effects of Exenatide Once-Weekly Injection on Glucose Control and Safety in Asian Subjects

Exenatide

Type 2 diabetes

BMI 21-35Ph 3Completed42Sep 20102results
NCT01455896A Study to Evaluate Cardiovascular Outcomes in Patients With Type 2 Diabetes Treated With ITCA 650

Exenatide

Cardiovascular disease, Type 2 diabetes

HbA1c ≥6.5%Ph 3Completed42Mar 20162
NCT00877890A Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly in Subjects With Type 2 Diabetes Mellitus (DURATION-5)

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed41Oct 20095results
NCT00434954Effect of Exenatide Plus Metformin vs. Insulin Aspart Plus Metformin on Glycemic Control and Hypoglycemia in Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-40Ph 3Completed39Jun 20092results
NCT00870194A Comparison of Adding Exenatide With Switching to Exenatide in Patients With Type 2 Diabetes Experiencing Inadequate Glycemic Control With Sitagliptin Plus Metformin

Exenatide

Type 2 diabetes

BMI 20-45Ph 4Completed36Apr 20101results
NCT02638805Study of the Safety and Tolerability of Switching to ITCA 650 in Patients With Type 2 Diabetes Receiving Liraglutide

Exenatide, Liraglutide

Type 2 diabetes

BMI 25-45Ph 3Completed36Oct 2017
NCT01554618Safety and Efficacy Study of Exenatide Once Weekly in Adolescents With Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 6.5-11%Ph 3Completed35May 20201results
NCT01003184Efficacy of Once-Weekly Exenatide Versus Once or Twice Daily Insulin Detemir in Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed34Jul 20111results
IMPERIUMA Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)

Exenatide, Liraglutide

Type 2 diabetes

HbA1c 7.3-10.9%Ph 4Terminated34Oct 20151results
NCT00044694Evaluation of the Effect on Glucose Control and the Safety and Tolerability of AC2993 in Patients With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI 27-45Ph 2Completed33May 20031
NCT00360334A Study Comparing Exenatide With Basal Insulin in Achieving a Target HbA1c With Minimum Weight Gain in Type 2 Diabetes Patients

Exenatide

Type 2 diabetes

BMI ≥27Ph 3Completed31Apr 20082results
NCT02288273Study to Evaluate the Effect of BYDUREON on 24-hour Glucose Control in Metformin Treated Patients With Type 2 Diabetes.

Exenatide

Type 2 diabetes

HbA1c 7-10%Ph 4Completed29Aug 2015results
NCT00099619Comparing Exenatide and Insulin Glargine in Type 2 Diabetes Patients for Whom Insulin is the Next Appropriate Therapy

Exenatide

Type 2 diabetes

BMI 25-40Ph 3Completed26Aug 20051
NCT00753896Safety of Exenatide Once Weekly in Patients With Type 2 Diabetes Mellitus Treated With Thiazolidinedione Alone or Thiazolidinedione in Combination With Metformin

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed26Jul 20091results
NCT00308139Effects of Exenatide Long-Acting Release on Glucose Control and Safety in Subjects With Type 2 Diabetes Mellitus(DURATION - 1)

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-45Ph 3Completed25Jul 200810results
NCT00603239Safety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using a Thiazolidinedione or a Thiazolidinedione and Metformin

Exenatide

Type 2 diabetes

BMI ≤45Ph 3Completed25Jul 20092results
NCT01147627Effect of Different Interventions on Glycemic Control and β-cell Function in Newly Diagnosed Type 2 Diabetic Patients

Exenatide

Type 2 diabetes

BMI ≤10Not applicableCompleted25Aug 2012results
IIH EVOLVEA Trial to Determine the Efficacy and Safety of Presendin in IIH

Exenatide

Pseudotumor Cerebri

Ph 3Terminated24Sep 2023results
NCT00085969Effect of Exenatide Monotherapy on Glucose Control in Subjects With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

Ph 2Completed23Jan 20041
NCT00935532Study to Evaluate the Efficacy and Safety of Exenatide Once-Weekly Injection Compared to Once-Daily Insulin in Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI 18-35Ph 3Completed22Sep 20102results
NCT01514149Dose-Ranging Study to Evaluate Efficacy and Safety of Weekly CJC-1134-PC in Patients With T2DM on Metformin Monotherapy

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 27-45Ph 2Terminated22May 2012results
NCT00135330An Evaluation of Exenatide and Rosiglitazone in Subjects With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI 25-40Ph 3Completed19Jul 20082results
NCT00381342Safety and Efficacy of Exenatide as Monotherapy

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-45Ph 3Completed19Sep 20073
NCT00477581A Study to Compare the Effects of Exenatide and Sitagliptin on Postprandial Glucose in Subjects With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI 25-45Ph 4Completed19Sep 20071
GETGOAL-XGLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin

Exenatide, GLP-1 / incretin class catch-all, Lixisenatide

Type 2 diabetes

Ph 3Completed18Nov 20102results
NCT00701935Effect of Exenatide on Abdominal Fat Distribution in Patients With Type 2 Diabetes Pretreated With Metformin

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 27-40Ph 2Terminated17Jan 2012results
NCT00500370A Pilot Study of Effects of Exenatide on Body Weight in Non-Diabetic, Obese Patients

Exenatide

Obesity / overweight

BMI ≥30Ph 2Completed16Feb 20081results
NCT00359879Comparison of Exenatide Taken Before Lunch and Dinner With Before Breakfast and Dinner in Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed15Jul 20071
BydureonA 12/24-weeks, Open, Multi-centre, Phase IV Study on Safety and Efficacy of 2mg Exenatide Once Weekly (Bydureon) in T2DM Patients.

Exenatide

Type 2 diabetes

Ph 4Completed15Dec 2016results
TEXAISTrial of EXenatide in Acute Ischaemic Stroke

Exenatide

Stroke

Ph 2Unknown15Oct 20211
NCT00324363Safety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Metformin or Sulfonylureas and Metformin

Exenatide

Type 2 diabetes

BMI 21-35Ph 3Completed14Apr 20072
NCT00382239A Study to Assess the Effect on Glucose Control and Safety and Tolerability of LY2148568 In Japanese Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

Ph 2Completed14May 20072
NCT00516048An Exploratory Study of the Effect of Treatment Interruption on Safety of Exenatide in Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c ≤10.5%Ph 3Completed13Apr 2008results
NCT00577824Efficacy and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Who Are Treated With Oral Antidiabetic(s)

Exenatide

Type 2 diabetes

HbA1c 7-10%Ph 3Completed12Nov 20083results
FLAT-SUGARFLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR)

Exenatide

Type 2 diabetes

BMI 25-45 · Established CVDPh 4Completed12Jul 201446results
CRANIOEXEEfficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy

Exenatide

Hypothalamic / syndromic obesity, Obesity / overweight

Ph 3Completed11Jun 20181
SEVERALSEMAGLUTIDE VERSUS GLP-1 RECEPTOR AGONISTS. EFFECTIVENESS , SAFETY AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS 2. OBSERVATIONAL, PROSPECTIVE AND MULTICENTER STUDY. SEVERAL STUDY.

Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Lixisenatide, Semaglutide

Obesity / overweight, Type 2 diabetes

BMI ≥30Completed11Nov 202314
NCT00375492Effect on Weight Loss of Exenatide Versus Placebo

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-39.9Ph 3Completed10Feb 20081results
EMPRESExenatide for Myocardial Protection During Reperfusion Study

Exenatide

Cardiovascular disease

Ph 2Unknown10Jul 2017
EXCEEDA Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With Those Who Initiated Other Non-Glucagon-Like Peptide 1 Receptor Agonists Based Glucose Lowering Drugs

Exenatide

Type 2 diabetes

Recruiting8Oct 2026
NCT01928329A Phase II Trial to Examine the Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients With Type I Diabetes

Exenatide

Type 1 diabetes

HbA1c 6.5-9.5%Ph 2Completed8Jun 2018results
NCT00103935Study Examining Exenatide Long-Acting Release in Subjects With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-45Ph 2Completed7Oct 20051
NCT00516074A Study to Assess the Effect of Exenatide Treatment on Mean 24-Hour Heart Rate in Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-40Ph 3Completed6Apr 20081results
COMBAT-MICOMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial

Exenatide

Cardiovascular disease

Ph 3Completed6Aug 20195
GLP-1REWINGLP-1 REceptor Agonists and Real World EvIdeNce

Dulaglutide, Exenatide, Liraglutide, Lixisenatide

Type 2 diabetes

Unknown6Feb 20196
ON TARGET DMComparison of Type 2 Diabetes Pharmacotherapy Regimens

Exenatide, Liraglutide

Type 2 diabetes

Completed6Dec 20244results
NCT00099333Study of the Safety of Substituting Exenatide for Insulin in Patients Using Insulin and Oral Antidiabetic Agents

Exenatide

Type 2 diabetes

BMI 27-40Ph 2Completed5Aug 20052
NCT00254254A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Tolerability of Exenatide in Adolescent Subjects With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

HbA1c 6-11%Ph 2Completed5Feb 20071
NCT02020616A Study of the Safety and Effectiveness of LY3053102 in Participants With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 23-45Ph 1/2Terminated5Feb 2015results
NCT02303730Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes

Exenatide

MASH / NAFLD / liver fibrosis, Obesity / overweight, Type 2 diabetes

BMI ≥24Ph 4Completed5Nov 201711
NCT04269642SR-Exenatide (PT320) to Eveluate Efficacy and Safety in Patients With Early Parkinson's Disease

Exenatide

Parkinson's disease

Ph 2Unknown5Sep 2021
BESTMEDBESTMED: Observational Evaluation of Second Line Therapy Medications in Diabetes

Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Semaglutide

Type 2 diabetes

HbA1c 7-11%Unknown5Jun 20243
NCT00806520Use of Continuous Glucose Monitoring Combined With Ambulatory Glucose Profiles to Characterize Glycemic Control

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-45Completed5Aug 2011
NCT00612794A Study to Examine Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Exenatide Once Weekly in Japanese Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 6.5-10%Ph 1Completed4May 20081
NCT00747968The Effect of the GLP-1 Analogue Exenatide on Type 2 Diabetes in CNS and Heart During Hyperglycemia Assessed by PET

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

BMI 20-45Ph 2/3Completed4Nov 20101
NCT02320045Study to Evaluate Pharmacokinetics of ITCA 650 in Subjects With Renal Impairment Compared to Normal Subjects

Exenatide

Healthy volunteers, Renal impairment

BMI 22-40Ph 1Completed4Jul 2015
NCT03419624The Potential of Dapagliflozin Plus Exenatide in Obese Insulin-resistant Patients

Exenatide

Obesity / overweight, Type 2 diabetes

BMI ≥30Ph 3Terminated4Apr 201919
DIRECTGLPDIabetes REsearCh on Patient sTratification (DIRECT): GLP-1R Agonists

Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Type 2 diabetes

HbA1c ≥7.5%Not applicableCompleted4Jul 2015
NCT00044668Evaluation of the Effect on Glucose Control and Safety of AC2993 in Patients With Type 2 Diabetes Treated With Metformin, Sulfonylurea, or Metformin and Sulfonylurea Combination

Exenatide

Type 2 diabetes

BMI 25-45Ph 3Completed3Sep 20052
NCT00097500Effects of Exenatide and Insulin Glargine in Subjects With Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 3Completed3Dec 20095results
NCT00622323Post Marketing Surveillance Study of Byetta ™ (Exenatide) Use Among Filipino Patients

Exenatide

Type 2 diabetes

Completed3Sep 2009
NAFLDRole of Exenatide in NASH-a Pilot Study

Exenatide

MASH / NAFLD / liver fibrosis, Type 2 diabetes

Ph 2/3Completed3Aug 201011results
MEXELINHow Glargine Insulin, Oral Diabetes Medications and Exenatide May Improve Blood Sugar Control and Weight Gain in Type 2 Diabetics

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-45Ph 4Completed3Oct 2009results
NCT00775684Effect of Exenatide, Sitagliptin or Glimepiride on Functional ß -Cell Mass

Exenatide

Prediabetes / glucose intolerance, Type 2 diabetes

Not applicableCompleted3Nov 20128results
EXEPUMPEffects of Exenatide on Glycemic Control and Weight in Continuous Subcutaneous Insulin Infusion (CSII) Type 2 Treated Patients With Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-45Ph 2/3Unknown3May 2017
NCT01798264Open Label, 4 Week Study of ITCA 650 in Adults With Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c ≥6.5%Ph 1Completed3May 20091results
ECHOEnergy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity

Exenatide, GLP-1 / incretin class catch-all

Hypothalamic / syndromic obesity, Obesity / overweight

BMI ≥95Ph 3Completed3Mar 2020results
NCT00508287Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of BMS-686117 in Subjects With Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 6-10%Ph 1Completed3Nov 2007
NCT01843127A Study to Evaluate the Effect of Ranolazine on Postprandial Glucagon in Subjects With Type 2 Diabetes.

Exenatide

Type 2 diabetes

BMI 20-40Ph 1Completed3Sep 2013
NCT00241423Effect of Exenatide on 24-Hour Blood Glucose Profile Compared With Placebo in Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-50Ph 2Completed2Jun 20071
NCT00546728The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes

Exenatide

Obesity / overweight, Prediabetes / glucose intolerance

Ph 4Completed2Jul 20111results
AGREEThe Effects of Exenatide After Gastric Restriction

Efpeglenatide, Exenatide

Bariatric Surgery, Obesity / overweight

BMI ≥40Ph 2/3Unknown2Dec 2010
NCT01061775Effects of Exenatide on Hypothalamic Obesity

Exenatide

Hypothalamic / syndromic obesity, Obesity / overweight

Ph 1/2Completed2Jul 2013results
NCT01104701A Study to Examine the Efficacy, Safety and Tolerability, and Pharmacokinetics of Exenatide Once Monthly Suspension

Exenatide

Type 2 diabetes

HbA1c 7.1-11%Ph 2Completed2Dec 20101results
NCT01136798Impact of Exenatide on Sleep in Type 2 Diabetes

Exenatide

Type 2 diabetes

Not applicableCompleted2Sep 2016results
NCT01237197Exenatide in Extreme Pediatric Obesity

Exenatide

Obesity / overweight

Ph 2Completed2May 20121results
NCT01297062A Safety Study to Assess the Effects of Therapeutic and Supratherapeutic Exenatide Concentrations on QT Interval in Healthy Subjects

Exenatide

Healthy volunteers, Obesity / overweight

BMI 25-35Ph 1Completed2Apr 2011results
NCT01664624Roflumilast Plus Alogliptin Proof-of-Mechanism Study in Type2 Diabetes

Exenatide

Type 2 diabetes

BMI 23-45Ph 1Completed2Nov 2012results
FPSEffects of Obesity Treatments on Food Preferences and Metabolism

Exenatide, Liraglutide

Bariatric Surgery Candidate, Obesity / overweight

BMI ≥30Completed2Oct 2017results
NCT02455076Exenatide Inpatient Trial: A Randomized Controlled Pilot Trial on the Safety and Efficacy of Exenatide (Byetta®) Therapy for the Inpatient Management of Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 25-45Ph 4Completed2Mar 20181results
NCT02793154An Exploratory Study on the Effects of Repeat Doses of Albiglutide Compared to Exenatide on Gastric Myoelectrical Activity and Gastric Emptying in Type 2 Diabetes Mellitus Subjects

Albiglutide, Exenatide

Type 2 diabetes

BMI 2-35Ph 4Terminated2Mar 2017results
Combat-JUDODouble-blinded, 6 Months Study With Bydureon® or Placebo in Adolescents With Obesity to Explore Changes in BMI

Exenatide

Obesity / overweight

BMI ≥2Ph 2Completed2Sep 20161
DRINNLong-acting Exenatide and Cognitive Decline in Dysglycemic Patients

Exenatide

Alzheimer's / cognition, Prediabetes / glucose intolerance

HbA1c 5.7-6.4%Ph 3Unknown2Jul 20194
NCT04027023Evaluation of the Impact of Intensive Short-Term Drug Therapy in Patients With Type 2 Diabetes Mellitus

Exenatide, Liraglutide

Type 2 diabetes

HbA1c ≤10%Ph 4Unknown2Apr 2021
NCT05610800Exenatide for Smoking Cessation and Prevention of Weight Gain

Exenatide

Alcohol / substance use, Obesity / overweight

BMI ≥25Ph 2Completed2Nov 20252
NCT00572689Pilot Study of Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes

Exenatide

Gestational diabetes

FemalePh 4Withdrawn2Aug 2015
NCT00672399Electrophysiological Effects of a Single 10 μg Dose of Exenatide on the 12-Lead Electrocardiogram QT Interval in Healthy Subjects

Exenatide

Healthy volunteers

BMI 19-35Ph 1Completed2Jul 2008
NCT01076842Efficacy Evaluation of Different Medication Combination in Type 2 Diabetes Treatment

Exenatide

Type 2 diabetes

BMI ≤40Ph 4Completed2Apr 2011
BCB119Autoinjector Device Assessment Study

Exenatide

Healthy volunteers

BMI 22-45Ph 1Completed2Dec 2013
NCT02641990Study of the Effect of ITCA 650 on the PK/PD of Oral Contraceptive in Healthy Female Subjects

Exenatide

Healthy volunteers

BMI 19-32Ph 1Completed2Feb 2016
NCT03182192GLP1R-imaging in Hypoglycemia

Exenatide

Bariatric Surgery

Ph 1Unknown2Jul 2024
NCT03182231GLP1-imaging Before and After Bariatric Surgery

Exenatide

Bariatric Surgery, Obesity / overweight, Type 2 diabetes

FemalePh 1/2Unknown2Jul 2023
INCA-BARIncretin Hormone Antagonism After Bariatric Surgery

Exenatide

Bariatric Surgery, Healthy volunteers

Not applicableCompleted2Apr 2021
NCT04159766A Study With NLY01 in Subjects With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 22-35Ph 2Completed2Dec 2020
Ver-A-imageA GLP-1 Receptor PET Imaging Substudy Within the VER-A-T1D Trial Investigating the Effects on Beta Cell Mass

Exenatide

Type 1 diabetes

Ph 2Unknown2Apr 2025
NCT01511393An Active Surveillance Program for Cases of Medullary Thyroid Carcinoma (MTC)

Dulaglutide, Exenatide, Liraglutide, Semaglutide

Oncology

By invitation1Dec 20391
GLORIOUSGLP-1 and Hyperoxia for Organ Protection in Heart Surgery

Exenatide

Cardiovascular disease

Not applicableActive, not recruiting1Sep 20243
BASIC2Brain Activation and Satiety in Children 2

Exenatide, GLP-1 / incretin class catch-all

Obesity / overweight

Age 10-12Ph 3Active, not recruiting1Aug 2025
CER-4-T2DComparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study

Albiglutide, Dulaglutide, Exenatide, Liraglutide, Lixisenatide, Semaglutide

Type 2 diabetes

Active, not recruiting1May 2026
GAPP-SVDGLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)

Exenatide

Alzheimer's / cognition

Ph 2Recruiting1May 2026
NCT06257966A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin

Dulaglutide, Exenatide

Type 2 diabetes

BMI 18.5-35Ph 3Active, not recruiting1Oct 2026
NCT06449235Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh

Albiglutide, Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Lixisenatide, Semaglutide

Type 2 diabetes

HbA1c 7-10%Ph 4Not yet recruiting1Apr 2025
NCT06725693Glucagon-like Peptide-1 Receptor PET/CT in GLP-1R Related Disease

Exenatide

Oncology

Recruiting1Nov 20271
META-BETAFood (Poly)Phenol Metabotypes and Beta-cell Mass and Function.

Exenatide

Healthy volunteers

Not applicableRecruiting1Dec 20253
DASH-CKMHUsing Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Real-world Settings (DASH-CKMH)

Albiglutide, Dulaglutide, Exenatide, Liraglutide, Lixisenatide, Semaglutide, Tirzepatide

Metabolic syndrome

Active, not recruiting1Jun 2029
ADIPO-CKDClinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD

Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Semaglutide, Tirzepatide

Chronic kidney disease, Obesity / overweight, Type 2 diabetes

Recruiting1Jul 202715
NCT00064714Effect of AC2993 With or Without Immunosuppression on Beta Cell Function in Patients With Type I Diabetes

Exenatide

Type 1 diabetes

BMI ≥20Ph 2Completed1Mar 20084
NCT00254800The Effects of Exenatide on Oral Contraceptive Pharmacokinetics in Healthy Females

Exenatide

Healthy volunteers

BMI 19-35Ph 1Completed1Aug 20061
NCT00313001Effects of Biphasic Insulin Aspart 70/30 vs. Exenatide in Type 2 Diabetes Patients Not Reaching Blood Glucose Targets on Metformin and a Sulfonylurea.

Exenatide

Type 2 diabetes

HbA1c ≥8%Ph 3Completed1Jul 20071
NCT00344851Exenatide and Metformin Therapy in Overweight Women With PCOS

Exenatide

Obesity / overweight, PCOS

BMI ≥27Ph 2Completed1Jun 20071
NCT00353834The Effect of Exenatide Compared to Lantus Insulin on Vascular Function in Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c ≥7%Ph 4Completed1Sep 2010results
NCT00456300Role of Exenatide in Type 1 Diabetes

Exenatide

Type 1 diabetes

HbA1c ≤8.5%Ph 2Completed1Mar 20091results
NCT00456885The Effect of Exenatide on Weight and Hunger in Obese, Healthy Women

Exenatide

Obesity / overweight, Prediabetes / glucose intolerance

BMI 28-35Ph 4Completed1Sep 20101results
NCT00529204Effects Of Exenatide On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Fatty Liver Disease

Exenatide

MASH / NAFLD / liver fibrosis, Obesity / overweight, Type 2 diabetes

BMI ≥35Ph 2Terminated1Jul 20091results
NCT00551590Effect of Sitagliptin on Incretin Effect in Patients With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI ≤40Ph 1Completed1Dec 20084
NCT00566813Islet Transplantation in Type 1 Diabetic Patients Using the Edmonton Protocol of Steroid Free Immunosuppression

Exenatide

Type 1 diabetes

Ph 1/2Completed1Jul 20101results
NCT00569907Observational Study of Interstitial Glucose Monitoring With Continuous Glucose Monitoring to Track Patients Treated With Exenatide

Exenatide

Type 2 diabetes

HbA1c 7.1-11%Completed1May 20094
NCT00623545Bioenergetic Alterations After Exenatide Administration

Exenatide

Obesity / overweight

BMI 30-40Ph 4Completed1Apr 20102results
NCT00679042Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol

Exenatide

Type 1 diabetes

Ph 3Active, not recruiting1Jul 20172results
NCT00729326Comparison of the Effect of Exenatide Versus Sitagliptin on 24-hour Average Glucose in Patients With Type 2 Diabetes on Metformin or a Thiazolidinedione

Exenatide

Type 2 diabetes

BMI 25-45Ph 4Completed1Oct 2009results
NCT00736229Intravenous Exenatide in Coronary Intensive Care Unit (ICU) Patients

Exenatide

Cardiovascular disease, Prediabetes / glucose intolerance

Ph 4Completed1Jun 20111results
PREDEXPREDnisolone-induced Beta-cell Dysfunction Prevented by EXenatide

Exenatide

Healthy volunteers

BMI ≤28Not applicableCompleted1Jan 20101
NCT00766857Effects of Exenatide in Type 2 Diabetic Patients With Congestive Heart Failure

Exenatide

Heart failure, Type 2 diabetes

HbA1c 6.5-10%Ph 4Completed1Dec 20121
NCT00799435Evaluating the Use of Exenatide in People With Type 2 Diabetes and Diastolic Heart Failure

Exenatide

Heart failure, Type 2 diabetes

Ph 4Terminated1Apr 2012results
NCT00835328Effect of Exendin (9-39) on Glucose Requirements to Maintain Euglycemia

Exenatide

Prediabetes / glucose intolerance

Age ≤12Ph 1/2Terminated1Jan 2017results
POSTCON IIPharmacological Postconditioning to Reduce Infarct Size Following Primary PCI

Exenatide

Cardiovascular disease

Ph 4Completed1Dec 20093
PIO-EXEffect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function

Exenatide

Healthy volunteers, Prediabetes / glucose intolerance, Type 2 diabetes

HbA1c ≥7%Ph 4Completed1Jul 20101results
NCT00845507Exenatide for the Treatment of Weight Gain Associated With Olanzapine in Obese Adults

Exenatide

Obesity / overweight, Psychiatric (schizophrenia / bipolar / depression)

BMI ≥30Ph 4Completed1Jul 20151results
NCT00855439Evaluation of Exenatide in Patients With Diabetic Neuropathy

Exenatide

Diabetic neuropathy, Type 2 diabetes

HbA1c ≥7%Not applicableCompleted1May 20141results
NCT00856609The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects

Exenatide

Obesity / overweight

BMI ≥30Ph 3Completed1Sep 20166results
NCT00882050Intravenous Exenatide (Byetta) During Surgery

Exenatide

Perioperative / gastric aspiration risk

Ph 1/2Completed1Apr 2016results
NCT00886626GLP-1 Therapy for Weight Loss and Improved Glucose Tolerance in Obese Children

Exenatide

Obesity / overweight

Ph 2Completed1Feb 20111results
NCT00894322A Study to Examine the Pharmacokinetics, Tolerability, Safety and Efficacy of Exenatide Once Weekly Suspension

Exenatide

Healthy volunteers, Type 2 diabetes

BMI 23-35Ph 1/2Completed1Aug 2009results
NCT00937079Whole Body 111In-exendin-4 Imaging Study in Insulinoma Patients

Exenatide

Oncology

Completed1Dec 20112
NCT00964262A Study to Evaluate Safety and Pharmacokinetics/Pharmacodynamics of Sustained Release(SR) Exenatide

Exenatide

Healthy volunteers

Male · Healthy volunteersPh 1Completed1Oct 20101
NCT00971659Adjunctive Therapy of Exenatide or Sitagliptin to Insulin Glargine in Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 7-10%Ph 1Completed1Sep 20081
NCT00974272Effects of Exenatide on Postprandial Hyperlipidemia and Inflammation

Exenatide

Dyslipidemia, Prediabetes / glucose intolerance, Type 2 diabetes

Ph 4Completed1Nov 20082
NCT01006889Adding Exenatide to Insulin Therapy for Patients With Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease

Exenatide

MASH / NAFLD / liver fibrosis, Type 2 diabetes

Ph 4Completed1Dec 2009results
NCT01046721Study Looking at Cardiovascular Effects of Exenatide, Its Blood Pressure Lowering Effect and Its Mechanisms

Exenatide

Healthy volunteers

BMI 20-27Not applicableCompleted1Dec 20121
NCT01056549Exenatide (Byetta ®) Regulation of Intestinal and Hepatic Lipoprotein Particle Production in Humans

Exenatide

Healthy volunteers

BMI 20-25Not applicableCompleted1Sep 20111
NCT01077323A Retrospective Cohort Study of Acute Pancreatitis in Relation to Use of Exenatide and Other Antidiabetic Agents

Exenatide

Type 2 diabetes

Completed1Mar 2008results
NCT01089569Continuous Glucose Monitoring Evaluation of Exenatide Twice Daily Versus Insulin Glargine

Exenatide

Type 2 diabetes

HbA1c ≥7%Not applicableCompleted1May 20132results
NCT01107717Durability of Combination Therapy With Exenatide/Pioglitazone/Metformin vs. Conventional Therapy in New Onset T2DM

Exenatide

Type 2 diabetes

Ph 4Completed1Feb 20232results
NCT01154933Exeantide in Type 2 Diabetes on Insulin

Exenatide

Obesity / overweight, Type 2 diabetes

BMI ≥30Ph 2Completed1Nov 20111results
NCT01174810Exendin-4 as a Treatment for Parkinson's Disease - Pilot Study

Exenatide

Parkinson's disease

Ph 2Unknown1Mar 20131
NCT01181986The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes

Exenatide

Prediabetes / glucose intolerance, Type 2 diabetes

HbA1c ≤8%Ph 4Completed1Dec 2012results
NCT01208649Effects of Exenatide (Byetta®) on Liver Function in Patients With Nonalcoholic Steatohepatitis (NASH)

Exenatide

MASH / NAFLD / liver fibrosis

Ph 4Completed1Sep 2010
NCT01235819Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus

Exenatide

Type 1 diabetes

Ph 4Completed1Sep 20111
EXAMIEffect of Additional Treatment With EXenatide in Patients With an Acute Myocardial Infarction (the EXAMI Trial)

Exenatide

Cardiovascular disease

Ph 3Unknown12
NCT01255163A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease

Exenatide

Alzheimer's / cognition

Ph 2Terminated1Nov 20165results
NCT01269034New Onset Type 1 Diabetes: Role of Exenatide

Exenatide

Healthy volunteers, Type 1 diabetes

Healthy volunteersPh 4Completed1Jan 2017results
NCT01269047Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia

Exenatide, Pramlintide

Type 1 diabetes

HbA1c ≤9%Ph 4Completed1Aug 2016results
Braini-ExThe Effect of GLP-1 Receptor Activation on Central Reward and Satiety in Obesity and Diabetes

Exenatide

Healthy volunteers, Obesity / overweight, Type 2 diabetes

BMI ≤25Not applicableCompleted1Oct 20131
SPPSThe Safety,Preliminary Pharmacodynamics and Pharmacokinetics Study of rExenatide-4 in Chinese Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

HbA1c 7-13%Ph 2Unknown1Dec 20111
ExenatideImpact of Exenatide on Cardiovascular Exercise Performance in Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI ≤35Not applicableCompleted1Dec 2014results
ExecutiveGlucagon-like Peptide 1 Agonist Exenatide for Improved Glucose Control and Cardiac Function in Patients With Aortocoronary Bypass

Exenatide

Cardiovascular disease, Heart failure, Perioperative / gastric aspiration risk

Ph 3Completed1May 20141
CMBDChanges in Bone Turnover With Exposure to a GLP-1 Receptor Agonist

Exenatide

Type 2 diabetes

HbA1c 6.5-9%Ph 4Terminated1Aug 2015results
NCT01429506Efficacy of Laparoscopic Sleeve Gastrectomy and Intensive Medical Management in Obese Type 2 Diabetes

Exenatide

Bariatric Surgery Candidate, Obesity / overweight, Type 2 diabetes

BMI ≥27.5Not applicableCompleted1Aug 2012
NCT01432405Effect Of Exenatide Treatment on Liver Fat Content in Patients With Diabetes

Exenatide

Type 2 diabetes

Ph 4Completed1Jul 20081results
NCT01435980Study of Comparison the Treatment Effect Between Gastric Bypass and Exenatide in Type 2 Diabetes

Exenatide

Bariatric Surgery Candidate, Obesity / overweight, Type 2 diabetes

BMI ≥35Ph 4Unknown1Jan 2016
NCT01444898Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome

Exenatide

Hypothalamic / syndromic obesity, Obesity / overweight

Not applicableCompleted1May 201310results
NCT01484873Weight Loss Study for Patients With Obesity Due to Craniopharyngioma or Other Brain Tumor

Exenatide

Hypothalamic / syndromic obesity, Obesity / overweight

BMI ≥30Ph 2Completed1Mar 20151results
NCT01501084Effects of the GLP-1 Exenatide on Satiety in Lean and Obese Women

Exenatide

Healthy volunteers, Obesity / overweight

BMI 19-25Ph 1Completed1Dec 2012
NCT01507038Safety and Efficacy of YH14617 in Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI ≥23Ph 2Completed1Jan 2015
PEPSPharmacology of Exenatide in Pediatric Sepsis

Exenatide

Ph 1/2Withdrawn1Oct 20144
EMPIREMyocardial Protection of Exenatide in AMI

Exenatide

Cardiovascular disease

Ph 4Completed1Aug 20113
NCT01588418Acute Effect of Exenatide on Brain Glucose Metabolism

Exenatide

Obesity / overweight, Prediabetes / glucose intolerance, Type 2 diabetes

BMI 25-40Ph 4Completed1Jul 20152results
NCT01590433Weight Loss With Exenatide Treatment

Exenatide

Obesity / overweight

BMI 28-48Ph 4Completed1Jan 20191results
NCT01677104The Microvascular Function of GLP-1 and Its Analogues

Exenatide, Liraglutide

Healthy volunteers, Obesity / overweight, Type 2 diabetes

BMI ≤25Not applicableCompleted1Jul 20141
NCT01687582Effect of GLP-1 Analogs on Psoriasis in Type 2 Diabetic Patients

Exenatide, Liraglutide

Psoriasis / psoriatic arthritis, Type 2 diabetes

Not applicableCompleted1Dec 20122
PCSAMPhysical and Chemical Study of Atherosclerosis Mechanisms

Exenatide

Cardiovascular disease, Dyslipidemia, Hypertension, Metabolic syndrome, Obesity / overweight

Ph 4Completed1Dec 20091
NCT01744236SAFEGUARD: Pleiotropic Effects of Incretin Based Therapies

Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Healthy volunteers, Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 4Completed1Aug 20156
NCT01783717Effects of Exenatide on Obesity and/or Diabetes Mellitus Due to Hypothalamic Damage

Exenatide

Diabetes (other / unspecified), Hypothalamic / syndromic obesity, Obesity / overweight

Not applicableUnknown1Jan 2015
NCT01791465Pilot Study of Bydureon to Treat Diabetes in HIV-infected Adults

Exenatide

Diabetes (other / unspecified), HIV

BMI ≥25Ph 4Terminated1Dec 2014results
TAOTreatment of Antipsychotic-associated Obesity With a GLP-1 Analogue

Exenatide

Obesity / overweight, Psychiatric (schizophrenia / bipolar / depression)

BMI ≥30Ph 3Completed1Jun 20153
GLP-1-CPOPGLP-1 Receptor Targeting in Diabetic and Healthy Individuals

Exenatide

Healthy volunteers, Type 1 diabetes

Completed1May 20141
NCT01857895Feasibility Study of Exenatide by Continuous Subcutaneous Infusion

Exenatide

Healthy volunteers

Healthy volunteersPh 1Completed1Nov 20131
NCT01951651Effect of Exenatide on Liver and Heart Fat and Inflammation

Exenatide

Type 2 diabetes

Ph 4Completed1Oct 2012results
ExSTRESSExenatide for Stress Hyperglycemia

Exenatide

Cardiovascular disease, Perioperative / gastric aspiration risk

Ph 2/3Completed1Dec 20154
EXENATIDE-PDTrial of Exenatide for Parkinson's Disease

Exenatide

Parkinson's disease

Ph 2Completed1May 20161
NCT01988545GLP-1's Effect on Cardiac Parameters and Mesenteric Blood Flow

Exenatide

Healthy volunteers

Healthy volunteersNot applicableUnknown1Jun 2014
NCT02042664Effect of GLP-1 Receptor (GLP-1R) Agonists on Cardiac Function and on Epicardial Adipose Tissue (EAT) Volume and on Myocardial TG Content in Obese Diabetics

Exenatide

Obesity / overweight, Type 2 diabetes

BMI ≥30Ph 3Completed1Jan 20152
NCT02057172Glycaemic Control of Weekly LAPS-Exendin Versus Placebo in Subjects of Type 2 Diabetes

Efpeglenatide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Type 2 diabetes

HbA1c 7-10%Ph 2Completed1Oct 20141
NCT02058940Intravenous Exenatide in Patients With Acute Brain Injury

Exenatide

Brain Injuries

Ph 4Completed1Aug 2017results
NCT02059564A Phase 1b Study of LAPS-Exendin in Subjects of Type 2 Diabetes Mellitus

Efpeglenatide, Exenatide, Liraglutide

Type 2 diabetes

BMI 18-45Ph 1Unknown1Oct 20141
NCT02075281Effect of LAPS-Exendin on Body Weight in Obese Population

Efpeglenatide, Exenatide

Obesity / overweight

Healthy volunteersPh 2Completed1Jan 2015
NCT02081118Glycaemic Control of Monthly LAPS-Exendin Versus Placebo in Subjects of Type 2 Diabetes

Efpeglenatide, Exenatide

Type 2 diabetes

HbA1c 7-10%Ph 2Completed1Mar 2015
NCT02084251Clinical Trial for PB-119 in Healthy Subjects (Phase I)

Exenatide

Healthy volunteers

BMI 19-24Ph 1Completed1Nov 20141
NCT02090673Post-Marketing Surveillance Study: 12 To 24 Weeks Study On The Treatment Emergent Adverse Events In Patients With Type 2 Diabetes Taking Exenatide In Korea

Exenatide

Type 2 diabetes

Completed1Mar 20141
SAFEGUARDSafety Evaluation of Adverse Reactions in Diabetes

Exenatide, GLP-1 / incretin class catch-all

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 4Completed1Oct 2015
NCT02104739Effects of Antidiabetic Medications on the Postprandial State in Prediabetes

Exenatide

Obesity / overweight, Prediabetes / glucose intolerance

BMI 30-35Ph 4Completed1Mar 20171results
NCT02118376Effects of GLP-1 Receptor Agonist on Fat Redistribution and Inflammatory Status

Exenatide

Obesity / overweight, Type 2 diabetes

FemaleNot applicableUnknown1Dec 20141
NCT02127541New Imaging Procedure for the Localisation of Insulinoma

Exenatide

Oncology

Not applicableCompleted1Nov 20177
NCT02150707The Differential Effects of Diabetes Therapy on Inflammation

Exenatide, Liraglutide

Chronic kidney disease, Type 2 diabetes

Completed1Dec 20154
APPLELiver and Fat Regulation in Overweight Adolescent Girls

Exenatide

Obesity / overweight, PCOS

FemalePh 2/3Completed1Dec 20223results
NCT02160990Effect of Exenatide in Obese Patients With Accelerated Gastric Emptying

Exenatide

Obesity / overweight

BMI ≥30Ph 4Completed1Mar 20151results
NCT02162550Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus

Exenatide

Cardiovascular disease, Type 2 diabetes

HbA1c 6.5-10%Ph 4Unknown1Apr 20191
NCT02170324GLP-1 Agonism Stimulates Browning of Subcutaneous White Adipose Tissue in Obesity Men

Exenatide

Obesity / overweight

BMI ≥30Ph 4Completed1Jul 2015
PREVAILPreserving Beta-cell Function in Type 2 Diabetes With Exenatide and Insulin (PREVAIL)

Exenatide

Type 2 diabetes

BMI ≥23Ph 3Completed1Dec 20211
NCT02244164Pathophysiological Study of the Increase in Pancreatic Volume in Type 2 Diabetes Treatments.

Exenatide, Liraglutide, Lixisenatide

Type 2 diabetes

BMI 20-45Not applicableTerminated1Feb 20234
NCT02251431Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome

Exenatide

Chronic kidney disease, Type 2 diabetes

HbA1c 6.6-9.9%Ph 3Completed1Dec 20197results
DapalostExploratory Study to Investigate the Effect of Dapagliflozin and Exenatide Combined on Body Weight

Exenatide

Obesity / overweight

BMI 30-45Ph 2Completed1Mar 2016
NCT02325960A Comparison of Exenatide and Insulin Glargine

Exenatide

Type 2 diabetes

Ph 4Completed1Jul 20161
NCT02336659Influence of Gut Hormones on Food Intake After Roux-en-Y Gastric Bypass Surgery

Exenatide

Bariatric Surgery

Not applicableCompleted1May 2016
NCT02380521Exenatide Once Weekly, Cardiovascular Risk and Type-2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI ≥25Ph 4Completed1Jul 20166
NCT02417142Exenatide Weekly Injections as an Adjunctive Treatment in Patients With Schizophrenia

Exenatide

Psychiatric (schizophrenia / bipolar / depression)

Ph 4Completed1Jul 2019results
ExeQOLImpact of Perioperative Exenatide Infusion on Quality of Life in Cardiac Surgery Patients

Exenatide

Cardiovascular disease, Perioperative / gastric aspiration risk

Ph 2/3Completed1Jan 20175
GLIP1GLP-1 Analogs for Neuroprotection After Cardiac Arrest

Exenatide

Brain Injuries, Cardiovascular disease

Not applicableCompleted1Jun 20164
NCT02449603Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 21-35Ph 4Completed1Apr 20182
NCT02456428Incretin-based Drugs and the Risk of Heart Failure

Exenatide, Liraglutide

Type 2 diabetes

Completed1May 20151
NCT02467920Efficacy and Safety of Basal Insulin Glargine Combination With Exenatide Bid vs Aspart30 in T2DM

Exenatide

Type 2 diabetes

BMI 23-35Ph 4Completed1Dec 2017
NCT02475499Incretin-based Drugs and Pancreatic Cancer

Exenatide, Liraglutide

Type 2 diabetes

Completed1Apr 20151
NCT02476760Incretin-based Drugs and Acute Pancreatitis

Exenatide, Liraglutide

Type 2 diabetes

Completed1Apr 20151
NCT02496611Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON™) in Adolescents With Severe Obesity

Exenatide

Obesity / overweight

Age 12-17Ph 2Completed1Aug 20202results
EGLIPAThe Effect of the GLP-1 Receptor Agonists on Blood Levels of Lipoprotein (a)

Exenatide, Liraglutide, Lixisenatide

Type 2 diabetes

Ph 4Unknown1Jul 20153
RebuildEffects on Re-endothelialisation With Bydureon Treatment in Type 2 Diabetes Subjects

Exenatide

Cardiovascular disease, Type 2 diabetes

Ph 4Completed1Aug 20228
NCT02635386EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)

Exenatide

Obesity / overweight, PCOS

BMI ≥30Ph 3Completed1Jul 20201results
GHADDGut Hormones in Obesity, Nicotine and Alcohol Dependence

Exenatide

Alcohol / substance use, Obesity / overweight

BMI 28-50Early Ph 1Unknown1Aug 20199
NCT02802514A Study Comparing the Effect of Albiglutide With Exenatide on Regional Brain Activity Related to Nausea in Healthy Subjects

Albiglutide, Exenatide

Healthy volunteers

Healthy volunteersPh 4Terminated1Aug 2017results
DexlarEfficacy of Exenatide-LAR and Dapagliflozin in Overweight/Obese, Insulin Treated Patients With Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI ≥27Ph 4Withdrawn1Jun 2018
EGRABIS1The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Stroke

Exenatide, GLP-1 / incretin class catch-all

Stroke

Ph 2Unknown1Aug 2023
EGRABINS1The Effect of GLP-1 Receptor Agonist on Cerebral Blood Flow Velocity in Non-stroke Volunteers

Exenatide, GLP-1 / incretin class catch-all

Healthy volunteers

Ph 2Completed1Feb 20171
NCT02843399Economic Outcomes of EQW (Exenatide Once Weekly) vs. IG (Insulin Glargine) in T2D Patients Who Are New to Injectable Therapy

Exenatide

Type 2 diabetes

Completed1Dec 2016
NCT02844907Regulation of Insulin Secretion by the GLP-1 Receptor

Exenatide

Healthy volunteers, Obesity / overweight, Prediabetes / glucose intolerance, Type 2 diabetes

BMI ≤35Ph 4Terminated1Dec 2021results
NCT02887625Exenatide Plus Pioglitazone Versus Insulin in Poorly Controlled T2DM

Exenatide

Type 2 diabetes

HbA1c ≥7.5%Not applicableUnknown1May 20171
NCT02917057Subanalyses of Elderly Type 2 Diabetes Patients or Type 2 Diabetes Patients With Renal Impairment

Exenatide

Renal impairment, Type 2 diabetes

Completed1Aug 20151
NCT02962492An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes

Exenatide

Type 1 diabetes

BMI 20-30Not applicableCompleted1Feb 2021results
NCT02975297Exenatide Once Weekly for Smoking Cessation

Exenatide

Alcohol / substance use, Obesity / overweight, Prediabetes / glucose intolerance

BMI ≥25Ph 1/2Completed1Jan 20202results
NCT02981069Effect of Chronic Exenatide Therapy on Beta Cell Function and Insulin Sensitivity in T2DM

Exenatide

Type 2 diabetes

BMI 25-35Ph 4Completed1Jul 2022results
NCT02987348Clinical Outcomes of Exenatide Versus Basal Insulin

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

Completed1Jun 20151
exe01Exenatide and Brown Adipose Tissue

Exenatide

Healthy volunteers

BMI 18-25Ph 4Unknown1Jun 20181
EXENDAEffects of Combined Dapagliflozin and Exenatide Versus Dapagliflozin and Placebo on Ectopic Lipids in Patients With Uncontrolled Type 2 Diabetes Mellitus.

Exenatide, GLP-1 / incretin class catch-all

Obesity / overweight, Type 2 diabetes

BMI ≥25Ph 4Completed1Nov 20191
MAG1CMeal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetic Cases

Exenatide

Type 1 diabetes

BMI ≥22Ph 2Completed1Jun 20192
NCT03018665A Study of the Effect of Glucagon-like Peptide 1(GLP-1) Receptor Agonist in Combination With Metformin Therapy on Diabetes Remission in Subjects With Newly Diagnosed Type 2 Diabetes Who Are Overweight or Obese

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 24-40Ph 4Unknown1Dec 2021
1981GLP-1 Receptor Agonist Therapy and Albuminuria in Patients With Type 2 Diabetes

Exenatide

Chronic kidney disease, Type 2 diabetes

HbA1c ≤10%Ph 4Terminated1Jul 2019results
NCT03151005The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS

Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Obesity / overweight, PCOS

BMI ≥24Ph 4Completed1Apr 202112results
NCT03160261Effect of Exenatide on Cortisol Secretion

Exenatide

Healthy volunteers

Ph 4Completed1Dec 20171
NCT03167411Bexagliflozin Drug/Drug Interaction Study With Exenatide Injection

Exenatide

Healthy volunteers

BMI 18-32Ph 1Completed1Jun 2017results
EXALTDoes Treatment With GLP-1 Reduce Alcohol Intake in Patients With Alcohol Dependence?

Exenatide, GLP-1 / incretin class catch-all

Alcohol / substance use, Healthy volunteers

Ph 2Completed1Mar 20201
NCT03246451The Role of GLP-1 Receptor Signalling in the Glucose-lowering Effect of Metformin in Patients With T2D

Exenatide

Type 2 diabetes

BMI 23-35Not applicableCompleted1Dec 20171
NCT03331289Can Exenatide Prevent Increase in EGP in Response to Dapagliflozin-induced Increase in Glucosuria

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

BMI 21-45Ph 4Completed1Mar 20221results
NCT03350191A Clinical Study to Investigate if SAR425899 Binds to the Liver and Pancreas in Overweight to Obese Type 2 Diabetes Mellitus Patients

Exenatide, SAR425899

Obesity / overweight, Type 2 diabetes

BMI 28-38Ph 1Completed1Jun 20181
NCT03352869Research of Exenatide for Overweight/Obese PCOS Patients With IGR

Exenatide

Obesity / overweight, PCOS, Prediabetes / glucose intolerance

FemalePh 4Completed1Jul 20188
DECREASEDECREASE: Dapagliflozin Plus Exenatide on Central REgulation of Appetite in diabeteS typE 2

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 27-40Ph 4Completed1Nov 201921
NCT03444142Effect of Exenatide LAR or Dulaglutide on the Variability of 24-hour Heart Rate and Blood Pressure in Type 2 Diabetes

Dulaglutide, Exenatide

Type 2 diabetes

Ph 4Unknown1Nov 2021
NCT03492580A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease

Albiglutide, Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Lixisenatide

Cardiovascular disease, Type 2 diabetes

Established CVDCompleted1Apr 2018
NCT03645408The Effects of Exenatide, a GLP-1 Agonist, on Alcohol Self-Administration in Heavy Drinkers

Exenatide

Alcohol / substance use

Ph 1Terminated1Jul 2021results
NCT03671733Effects of GLP-1 RAs on Weight and Metabolic Indicators in Obese Patients

Exenatide, Liraglutide

Obesity / overweight

BMI ≥28Ph 3Unknown1Sep 2022
NLY01-H1A Phase 1 Study to Assess the Safety of NLY01 in Healthy Subjects

Exenatide

Healthy volunteers

BMI 18.5-32Ph 1Completed1Jul 20192
NCT03804411Prognostic Predictors of Response to Hypoglycemic Therapy

Exenatide, Liraglutide

Type 2 diabetes

HbA1c ≤1%Ph 4Unknown1Mar 2020
COCOAHaemodynamic Effects of GLP-1 and Glucagon in Healthy Male Volunteers

Exenatide

Healthy volunteers

BMI 18-30Not applicableCompleted1Nov 2021
GLP1-ex-vivoQuantitative GLP-1 Receptor Imaging Correlated to ex Vivo Distribution of In-111-exendin

Exenatide

Type 2 diabetes

Not applicableTerminated1Jun 20211
NCT03961256Assess the Efficacy and Safety of Exenatide SR for the Prevention of Diabetes After Kidney Transplantation

Exenatide

Prediabetes / glucose intolerance, Renal impairment

Ph 2Completed1Oct 2021results
NCT04029272Metformin vs Metformin Combined With GLP-1RA (Glucagon-like Peptide 1 Receptor Agonist) on Overweight/Obese PCOS Patients

Exenatide

Obesity / overweight, PCOS

BMI ≥25Ph 4Unknown1Feb 20202
NCT04184947Cardiovascular Outcomes SGLT-2 Inhibitors Versus GLP-1 Receptor Agonists

Dulaglutide, Exenatide, GLP-1 / incretin class catch-all, Liraglutide, Lixisenatide

Type 2 diabetes

Completed1Dec 20181
Exenatide-PD3Exenatide Once Weekly Over 2 Years as a Potential Disease Modifying Treatment for Parkinson's Disease

Exenatide

Parkinson's disease

Ph 3Completed1Feb 20242
NCT04303819The Effect of Exenatide on Fasting Bile Acids

Exenatide

Type 2 diabetes

Completed1Jan 20201
COCONUTEffect of Glucagon and Glucagon-like Peptide-1 Co-agonism on Cardiac Function and Metabolism in Overweight Participants with Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI ≥25Ph 4Completed1Oct 2022
NCT04347252Glucagon Regulation of Glucose Metabolism

Exenatide

Healthy volunteers

HbA1c ≤5.9%Ph 1Completed1Apr 2021
MSAExenatide Once-weekly as a Treatment for Multiple System Atrophy

Exenatide

Ph 2Completed1Mar 202433results
PB119Safety and Efficacy of Pegylated Exenatine Injection (PB-119) in Drug-naïve T2DM Subjects

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

BMI ≤40Ph 3Completed1Mar 20221
NCT04504396Safety and Efficacy of PB-119 in Subjects With Type 2 Diabetes and Not Well-controlled by Metformin Monotherapy

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

BMI ≤40Ph 3Completed1Sep 2022
GLP1R-T2DGlucagon Like Peptide 1 Receptor (GLP1R) Expression and Beta-cell Mass in Patients With Type 2 Diabetes

Exenatide

Type 2 diabetes

Not applicableUnknown1Jun 20221
FASTExenatide-test for Diagnosing Endogenous Hyperinsulinemic Hypoglycemia

Exenatide

Diabetes (other / unspecified), Prediabetes / glucose intolerance

Not applicableCompleted1Apr 20241
NCT04941521Exenatide for Treating Cocaine Use Disorder

Exenatide

Alcohol / substance use

Ph 1/2Completed1Nov 20211results
NCT04969627Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia.

Exenatide

Obesity / overweight, PCOS

BMI ≥24Ph 4Completed1Jan 2022
NCT05034783[68Ga]Ga-HBED-CC-exendin-4 and [68Ga]Ga-NOTA-exendin-4 PET/CT Imaging in the Same Group of Insulinoma Patients

Exenatide

Oncology

Early Ph 1Unknown1Oct 20221
NCT05328843Study to Evaluate the Pharmacokinetic Characteristics of Pegylated Exenatide Injection (PB-119) in Subjects With Different Degrees of Renal Insufficiency and Matched Subjects With Normal Renal Function

Exenatide

Healthy volunteers, Renal impairment

BMI 18-30Ph 1Unknown1Oct 2022
LIBERATE-1Assessment of Safety, Tolerability and Drug Levels of Exenatide Implant

Exenatide, GLP-1 / incretin class catch-all, Semaglutide

Healthy volunteers, Obesity / overweight

BMI 27-40Ph 1Completed1Aug 2025
NCT05762744Pharmacogenomics of GLP1 Receptor Agonists

Exenatide, GLP-1 / incretin class catch-all

Healthy volunteers

BMI 18-40Ph 1Terminated1Nov 20182results
NCT06247748Influence of JY09 on Pharmacokinetics of Metformin , Rosuvastatin , and Digoxin and the QT Interval Study in Overweight Chinese Subjects

Exenatide

Healthy volunteers, Obesity / overweight

BMI 24-28Ph 1Completed1Apr 2024
NCT00517283A Study by Scintigraphy to Evaluate the Effect of Exenatide on Gastric Emptying in Subjects With Type 2 Diabetes

Exenatide

Type 2 diabetes

BMI 19-40Ph 1Completed1Jun 2005
NCT00551343Gut Derived Hormones, Body Composition and Metabolism in Prader-Willi Syndrome

Exenatide, GLP-1 / incretin class catch-all

Healthy volunteers, Hypothalamic / syndromic obesity

Not applicableCompleted1Sep 2008
ExenatideExenatide Pregnancy Registry - Type 2 Diabetes in Pregnancy

Exenatide

Type 2 diabetes

FemaleTerminated1Apr 2016
NCT00642538A Study Designed to Determine the Safety and Pharmacological Response ofMKC253 Inhalation Powder in Adults With Type 2 Diabetes Mellitus

Exenatide, MKC253

Type 2 diabetes

BMI ≤32Ph 1Completed1Sep 2008
NCT00803920Continuous Glucose Monitoring (CGM) in Subjects With Type 2 Diabetes Taking Twice-Daily Exenatide or Once-Weekly Exenatide

Exenatide

Type 2 diabetes

BMI 25-45Completed1Feb 2008
NCT00948168Effect of Exenatide on Glucose Homeostasis Determinants in Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI 25-40Ph 4Completed1Jul 2009
T2DMThe Effect of Byetta and Symlin on Post-meal Meal Blood Sugar Levels in Children With Type 2 Diabetes

Exenatide, Pramlintide

Type 2 diabetes

HbA1c ≤8.5%Ph 4Completed1May 2011
SR-ExenatideStudy to Evaluate Safety and PK/PD of DA-3091 in Healthy Male Subjects

Exenatide

Healthy volunteers

Male · Healthy volunteersPh 1Completed1Apr 2012
REACT2The Impact of Food on Blood Sugar in People With Type 2 Diabetes

Exenatide

Type 2 diabetes

Completed1May 2013
ClosedloopClosed Loop System With Pramlintide Versus Exenatide

Exenatide, Pramlintide

Type 1 diabetes

HbA1c ≤8.5%Ph 1Completed1Jan 2013
NCT01270191The Effects of Short-Term Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients

Exenatide

Type 2 diabetes

HbA1c 7-9%Ph 4Unknown1Dec 2014
NCT01416649Impact of Exenatide on Sleep Duration

Exenatide

Type 2 diabetes

Completed1Apr 2021
NCT01452451Safety, Tolerability, Pharmacokinetics,Pharmacodynamics Study of LAPS-Exendin in Subjects of Type 2 Diabetes Mellitus

Efpeglenatide, Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

HbA1c 7-10%Ph 2Completed1Jun 2013
NCT01455883A Study to Evaluate ITCA 650 Compared to Glimepiride for the Treatment of Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 7.5-10.5%Ph 3Withdrawn1Jul 2014
NCT01455909A Study to Evaluate ITCA 650 Compared to Sitagliptin for the Treatment of Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 7.5-10%Ph 3Withdrawn1Jul 2014
NCT01455922A Study to Evaluate ITCA 650 Compared to Glimepiride as Add on Therapy for the Treatment of Type 2 Diabetes

Exenatide

Type 2 diabetes

HbA1c 7.5-10.5%Ph 3Withdrawn1Jul 2014
AGAC2Additional GLP-1 Analogue on CSII Treatment for Poorly Controlled Type 2 Diabetic Patients

Exenatide

Type 2 diabetes

HbA1c 8-12%Not applicableCompleted1Jun 2013
NCT01776788Effect of Short-Term Intensive Insulin Sequential Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients

Exenatide

Type 2 diabetes

BMI ≤10Ph 4Completed1Feb 2015
NCT01855490Study of the Acute Metabolic Effect of Exenatide in Type 1 Diabetes

Exenatide

Type 1 diabetes

Ph 1Completed1Jul 2013
NCT01876849An Open-Label Study Examining the Long-Term Safety of Exenatide Given Twice Daily to Patients With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

Ph 3Completed1Jul 2008
NCT01934816Incretin and KATP Channels

Exenatide, Liraglutide

Healthy volunteers

BMI ≤25Not applicableTerminated1Jan 2015
T2DMRSEffect on Beta Cell Function and Glycaemic Control After Insulin and Exenatide Sequential Therapy

Exenatide

Type 2 diabetes

BMI ≥3Ph 4Unknown1Jun 2015
NCT02302976GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration

Exenatide

Alcohol / substance use

Ph 1Completed1Aug 2018
NCT0256037668Ga-NOTA-exendin-4 PET/CT for the Localization of Insulinoma and Diagnosis of Nesidioblastosis

Exenatide

Oncology

Early Ph 1Unknown1Dec 2016
NCT02641899Study of the Effects of ITCA 650 on Gastric Emptying and Interaction of ITCA 650 on 4 Commonly Studied Drugs

Exenatide

Healthy volunteers

BMI 19-32Ph 1Completed1Mar 2016
NCT02650479Study of the Effects of Intravenous Exenatide on Cardiac Repolarization

Exenatide

Healthy volunteers

BMI 19-35Ph 1Completed1Apr 2016
NCT02685852Evaluating Exenatide for the Treatment of Postprandial Hyperinsulinemic Hypoglycemia

Exenatide

Bariatric Surgery

Ph 1Completed1Jul 2019
NCT02735031Exenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes

Exenatide, GLP-1 / incretin class catch-all

Type 1 diabetes

Ph 2/3Completed1Mar 2018
NCT02974244Comparison of the Effectiveness and Tolerability of Exenatide Once-weekly Compared to Basal Insulins

Exenatide

Type 2 diabetes

Completed1Oct 2014
NCT03059719Clinical Trial for PB-119 in Subjects With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

Ph 1Completed1Sep 2016
NCT03182296Visualizing Beta Cells in Patients With a History of Gestational Diabetes

Exenatide

Gestational diabetes, Healthy volunteers

BMI 17-30Not applicableUnknown1Jan 2026
NCT03199261A Study of Pharmacokinetic Comparison of Two Recombinant Exendin-4 Formulations in Chinese Healthy Male Subjects

Exenatide

Healthy volunteers

BMI 19-26Ph 1Completed1Jan 2017
PCOSResearch of Intensive Metabolic Intervention Before Pregnancy in PCOS

Exenatide

PCOS, Prediabetes / glucose intolerance

FemalePh 4Unknown1Dec 2018
NCT03456687Effects of Exenatide on Motor Function and the Brain

Exenatide

Parkinson's disease

Ph 1Completed1Oct 2020
GLP-1-CHIGLP-1 Receptor Expression in CHI

Exenatide

Prediabetes / glucose intolerance

Age ≤16Unknown1Feb 2019
iPAVEImaging Pituitary ActiVation by Exendin

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

Not applicableCompleted1Apr 2024
NCT03970044Effectiveness of Exenatide Plus Dapagliflozin on 24 Hour Glucose Variability Measured by CGM. A Proof of Concept.

Exenatide

Type 2 diabetes

BMI ≤45Ph 4Completed1Jun 2021
NCT04185350Clinical Evaluation of 68Ga-NOTA-MAL-Cys39-exendin-4 Positron Emission Tomography in the Detection of Insulinoma

Exenatide

Oncology

Early Ph 1Unknown1Apr 2020
NCT04305002Exenatide Treatment in Parkinson's Disease

Exenatide

Parkinson's disease

Ph 2Unknown1Oct 2023
NCT04379856Proof of Concept Study in Patients With Short Bowel Syndrome

Exenatide

Gastrointestinal (gastroparesis / short bowel / pancreatitis)

Ph 1/2Unknown1Dec 2020
NCT04897802Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)

Exenatide

Healthy volunteers

Healthy volunteersPh 4Completed1Apr 2024
NCT04979611The Clinical Application of 68Ga-NOTA-exendin-4 PET/CT in Detecting Insulinoma

Exenatide

Oncology

Ph 1Unknown1Aug 2025
ENTRAPExendin PET/CT for Imaging of Paragangliomas

Exenatide

Oncology

Unknown1Dec 2024
NCT05482789Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes

Exenatide

Gestational diabetes

FemalePh 4Recruiting1Dec 2025
BetaFITBetaFIT Study: Beta Cell Imaging After Faecal mIcrobiota Transplantation

Exenatide

Type 1 diabetes

BMI 18-30Ph 2Unknown1Feb 2024
NCT05662189Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes Mellitus

Exenatide

Healthy volunteers, Prediabetes / glucose intolerance, Type 1 diabetes, Type 2 diabetes

Not applicableRecruiting1Jul 2025
NCT06252623Exenatide For Reducing the Reinforcing Effects of Cocaine

Exenatide

Alcohol / substance use

Ph 1Withdrawn1Mar 2026
NCT06254014A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Placebo in T2DM Patients

Exenatide

Type 2 diabetes

BMI 18.5-35Ph 3Active, not recruiting1May 2026
NCT06256419Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DM

Exenatide, GLP-1 / incretin class catch-all

Type 2 diabetes

BMI 20-35Not applicableRecruiting1Jan 2028
NCT07340437Clinical Study of 18F-Exendin-4 in Insulinoma

Exenatide

Oncology

Completed1Oct 2025
CR059101A Single-Center, Open-Label, Single Ascending Dose Study of Exenatide Circular RNA-Lipid Nanoparticle Injection (CR059) in Chinese Subjects With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI ≤40Early Ph 1Recruiting1Aug 2026
TAG-MSTargeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis

Exenatide

Multiple sclerosis, Obesity / overweight

BMI ≥27Ph 2Recruiting1Jan 2030
NCT00782418A Study to Compare Methodologies for Assessing Glucose-Dependent Insulin Secretion (0000-104)(COMPLETED)

Exenatide

Healthy volunteers

BMI ≤26Ph 1Completed0Feb 20091results
NCT00845559The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults

Exenatide

Healthy volunteers, Obesity / overweight, Prediabetes / glucose intolerance

BMI ≥97Ph 4Withdrawn0Mar 2010
NCT01302327GLP Analogs for Diabetes in Wolfram Syndrome Patients

Exenatide

Wolfram Syndrome

Not applicableWithdrawn0Mar 20131
NCT02084654Exenatide and Weight Loss for Diabetes Prevention

Exenatide

Obesity / overweight, Prediabetes / glucose intolerance

BMI 27-37Ph 1Completed0Oct 2012
NCT02344641Efficacy and Mechanism of Exenatide on Improving Heart Function in Type 2 Diabetes With Heart Failure Patients

Exenatide

Heart failure, Type 2 diabetes

HbA1c 7-10%Not applicableUnknown0Dec 2016
GLP1-EX-GELOEffect of Gelofusine on GLP1-receptor Imaging

Exenatide

Healthy volunteers

BMI ≥30Ph 1/2Completed0May 2017
NCT02584075Evaluate the Effect of Exenatide Treatment on Coronary Artery Endothelial Function

Exenatide

Obesity / overweight, Type 2 diabetes

BMI ≥25Ph 4Unknown0Nov 2017
DIPITDiabetes Islet Preservation Immune Treatment

Exenatide

Type 1 diabetes

Ph 1/2Withdrawn0Jun 20242
NCT02690883Effect of Exenatide on 24h-UAER in Patients With Diabetic Nephropathy

Exenatide

Chronic kidney disease, Type 2 diabetes

BMI 18-35Ph 4Completed0Dec 201917
NCT03239119The Effectivity and Safety Study of rExenatide-4 in Chinese Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI ≤35Ph 3Unknown0Dec 2018
NCT03297879Comparison of Exenatide and Metformin Monotherapy in Overweight/Obese Patients With Newly Diagnosed Type 2 Diabetes

Exenatide

Obesity / overweight, Type 2 diabetes

BMI ≥24Ph 4Completed0Feb 20162
NCT04001231Study of Exenatide Once-Weekly Suspension in Chinese Patients With Type 2 Diabetes Mellitus

Exenatide

Type 2 diabetes

BMI 18.5-35Ph 1Withdrawn0Jul 2021
NCT00259896In-patient Study in Patients With Type 2 Diabetes Mellitus

Exenatide

Healthy volunteers, Type 2 diabetes

Ph 1Completed0
NCT01021527A Study to Assess the Effects of Exenatide on Insulin Secretion Rates Using a Graded Infusion of Intravenous Glucose (0000-099)(COMPLETED)

Exenatide

Healthy volunteers

MalePh 1Completed0Mar 2008
NCT01093729A Study of HM11260C in Healthy Male Subject

Efpeglenatide, Exenatide

Healthy volunteers

BMI 18-27Ph 1Completed0Oct 2010
NCT01602913Type II Diabetes Mellitus in Patients Exposed to Pravastatin and Paroxetine

Exenatide, Liraglutide

Completed0May 2012
NCT01767389Glucagon-like Peptide (GLP) Utilization and Safety

Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Type 2 diabetes

Completed0Dec 2013
NCT01818648Exenatide on GI Motor Function and Permeability in Short Bowel Syndrome

Exenatide

Gastrointestinal (gastroparesis / short bowel / pancreatitis)

Ph 4Withdrawn0Jan 2014
ALFA-1The Effect of GLP-1 on Postprandial Glucagon Secretion Independent of The Gastric Emptying Rate

Exenatide, GLP-1 / incretin class catch-all, Liraglutide

Type 1 diabetes

Ph 2/3Unknown0Nov 2015
NCT02895672GLP-1/Basal Insulin Combination Therapy

Exenatide, Liraglutide

Type 2 diabetes

Completed0Nov 2016
GLP-1-AHH68Ga-NODAGA-exendin-4 PET/CT for Diagnostic Imaging in AHH

Exenatide

Oncology

Ph 1/2Completed0Jan 2021