DelfaGLP-1 Atlas

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Completed

Incretin-based Drugs and the Risk of Heart Failure

Incretin-based Drugs and the Risk of Heart Failure: A Multi-center Network Observational Study

Assets

Exenatide / Liraglutide

Listed sites

1

Recruiting sites

—

Enrollment

1,499,650

actual

Study population

Type 2 diabetes

Key I/E criterion

—

Primary endpoint

•Heart-failure hospitalization

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT02456428
Org study IDQ13-06C

Timeline

Milestones

Study first posted2015-05-28estimated
Last update posted2016-04-19estimated
Study start2014-03 (month precision)
Primary completion2015-05actual (month precision)
Study completion2015-05actual (month precision)

Assets

Investigational agents

ExenatideLiraglutide

Study populations

Who this study enrolls

Type 2 diabetes

Eligibility

Who can enroll

Minimum age18 Years
SexAll
Healthy volunteersNot accepted
Sampling methodProbability sample

Study population text

In each jurisdiction, a base cohort will be assembled including all patients with a first-ever prescription for a non-insulin anti-diabetic drug. Base cohort entry is defined as the date of prescription or dispensation of a first-ever non-insulin anti-diabetic drug. From this base cohort, a study cohort will be formed consisting of all patients who initiated a new anti-diabetic drug class during the year in which incretin-based drugs entered the market in each jurisdiction or any time thereafter. Study cohort entry is defined by the prescription date of the newly-prescribed drug class. Two separate cohorts will be created based on the presence or absence of a history of HF prior to and including study cohort entry.

Inclusion criteria

•Patients with a first-ever prescription for a non-insulin anti-diabetic drug, including biguanides, sulfonylureas, thiazolidinediones, DPP-4 inhibitors, GLP-1 analogs, alpha-glucosidase inhibitors, meglitinides, or combinations of these drugs from the earliest availability of data at each site to the last date of availability of data.
•Patients with at least 1 year of history in the database.
•Patients at least 18 years of age.

Exclusion criteria

•Patients who died or left the cohort before the year the first incretin-based drug entered the market.
•Patients who never added-on or switched to a new anti-diabetic drug after incretin-based drugs entered the market up until June 30, 2014.
•Patients diagnosed with HIV or initiating HAART therapy before and at study cohort entry.

Endpoints (1)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Heart failure

1 endpoint
Primary/protocol endpoint

Hospitalization for incident heart failure

Time frame:Patients were followed from the date of study cohort entry until hospitalization for incident heart failure, censoring, or for up to 87 months.

Heart-failure hospitalization

time to event, event

SNOMED 84114007

Publications (1)

Bibliography

Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.

Registry references + supporting bibliography

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 1, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.