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Clinical Outcomes of Exenatide Versus Basal Insulin
Evaluation of the Clinical and Economic Outcomes Associated With Exenatide Versus Basal Insulin in People With Type 2 Diabetes
Lead sponsor
Assets
Exenatide / GLP-1 / incretin class catch-all
Listed sites
1
Recruiting sites
—
Enrollment
18,000
actual
Study population
Type 2 diabetes
Key I/E criterion
—
Primary endpoints
•HbA1c, change•Body weight, absolute change (kg)•Changes from baseline in composite outcomes of HbA1c<=7.0% and weight reduction (HbA1c <7.0% achievement, Body weight, % change)
Footprint
Where this trial recruits
Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.
Identifiers
Registered as
Timeline
Milestones
Assets
Investigational agents
Study populations
Who this study enrolls
Eligibility
Who can enroll
Study population text
This is a non-interventional study based on secondary data analysis. Patients received treatment under their standard care, no intervention was given by the study investigator. Patients will be identified and included in the study if they were defined by CPRD as being of acceptable research quality and classified as having type 2 diabetes who initiated exenatide or basal insulin as monotherapy or in combination with one or more other oral glucose-lowering therapies between January 2009 and December 2014. Exenatide once weekly (Bydureon) and exenatide twice daily (Byetta) are both investigated, and compared with matched basal insulin cohort. Patients will be excluded if they had received prior injectable diabetes therapy and had less than 90 days continuous exposure to the study drugs.
Inclusion criteria
Exclusion criteria
Endpoints (4)
What's being measured
Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.
Coverage by outcome category
Weight & body composition
1 endpointChanges from baseline in weight (kg)
Time frame:6, 12 and 24 months
Body weight, absolute change (kg)
change from baseline, improvement
Glycemic / diabetes
2 endpointsChanges from baseline in HbA1c (%)
Time frame:6, 12 and 24 months
HbA1c, change
change from baseline, improvement
LOINC 4548-4
Changes from baseline in composite outcomes of HbA1c<=7.0% and weight reduction
Time frame:6, 12 and 24 months
threshold achievement, improvement
componentsHbA1c <7.0% achievement, Body weight, % change
Other clinical outcomes
1 endpointHealth care utilization
Time frame:12 months
descriptive
Publications (1)
Bibliography
Records linked to this trial through ClinicalTrials.gov references, PubMed NCT search, and curated study seeds. 'Canonical' marks design/result papers; others are registry references or candidates.
Registry references + supporting bibliography
- Diabetes, obesity & metabolism2017 Aug (month)PMID28218819doi:10.1111/dom.12916via CT.gov background
Provenance
Sources
Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.