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CompletedPhase 1

A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin

A Single-Center, Open-Label Study to Evaluate the Effect of XW003 Injection on the Pharmacokinetics of Metformin, Warfarin, Rosuvastatin or Digoxin in Healthy Subjects

Asset

Ecnoglutide (XW003)

GLP-1 agonist

Listed sites

1

Recruiting sites

Enrollment

57

actual

Study population

Healthy volunteers

Key I/E criterion

BMI 20-30

Primary endpoints

Pharmacokinetics of metforminPharmacokinetics of S-warfarin and R-warfarinPharmacokinetics of rosuvastatin

Footprint

Where this trial recruits

Site locations as reported to ClinicalTrials.gov. Site count is not enrollment count; per-site enrollment is not available from source.

Identifiers

Registered as

NCT IDNCT06335134
Org study IDSCW0502-1016

Timeline

Milestones

Study start2023-07-14actual
Primary completion2024-01-08actual
Study first posted2024-03-28actual
Study completion2024-06-28actual
Last update posted2025-05-08actual

Assets

Investigational agents

Study populations

Who this study enrolls

Healthy volunteers

Eligibility

Who can enroll

Minimum age18 Years
Maximum age45 Years
SexAll
Healthy volunteersAccepted

Inclusion criteria

1. Male or female, 18-45 years old, inclusive;

2. BMI: 20.0 to 30.0 kg/m2 , body weight: ≥50.0kg.

3. Ability and willingness to participate in the study, give written informed consent, and comply with the study requirements and all protocol procedures.

Exclusion criteria

1. Presence of clinically significant conditions (including but not limited to respiratory system, cardiovascular system, gastrointestinal system, endocrine system, immune system, integumentary system, nervous system, ENT or other related diseases);

2. History of allergic diseases including asthma, urticaria or eczema, or history of sensitivity to GLP-1 products, digoxin, warfarin, rosuvastatin or metformin;

3. Known difficulty in swallowing tablets or history of gastrointestinal diseases affecting drug absorption;

4. History of receiving any procedures that might affect drug absorption, distribution, metabolism or excretion;

5. History of acute or chronic pancreatitis;

6. History of documented or suspected hypoglycemic episodes within 6 months prior to screening;

Endpoints (4)

What's being measured

Protocol endpoints and posted registry outcome measures, grouped into outcome categories. Composite endpoints show their component event types. Standard codes (LOINC, SNOMED CT) are shown where available.

Safety / tolerability / PK

4 endpoints
Primary/protocol endpoint

Pharmacokinetics of metformin: AUC0-inf

Time frame:up to 101 days

AUC₀–∞

concentration, descriptive

Primary/protocol endpoint

Pharmacokinetics of S-warfarin and R-warfarin: AUC0-inf

Time frame:up to 114 days

AUC₀–∞

concentration, descriptive

Primary/protocol endpoint

Pharmacokinetics of rosuvastatin: AUC0-inf

Time frame:up to 102 days

AUC₀–∞

concentration, descriptive

Primary/protocol endpoint

Pharmacokinetics of digoxin: AUC0-inf

Time frame:up to 112days

AUC₀–∞

concentration, descriptive

Provenance

Sources

Trial identity, design, statusClinicalTrials.gov API v2
Snapshot dateJuly 1, 2026
Endpoint classificationDelfa endpoint taxonomy v2 (May 13, 2026)
Results tableno registry results posted yet

Trial facts come from public ClinicalTrials.gov records. Endpoint categories are Delfa's classification of those records, not a ClinicalTrials.gov field. All figures reflect the July 1, 2026 snapshot.