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Oral / Subcutaneous · GLP-1 agonist

Ecnoglutide

15 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Distinct formulations of the same molecule

This molecule is developed in parallel as separate programs. They are not competing therapies (they share the same active drug) but differ by formulation, route, and developer. Trials below are labeled with their program code.

Trials

15

Active

7

Recruiting

3

Completed

8

Sites

46

Countries

3

Endpoints

135

Composite endpoints

8

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
5
Phase 1/2
1
Phase 2
4
Phase 3
5

Trials by status

Not yet recruiting
2
Recruiting
3
Active, not recruiting
2
Completed
8

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
54
Weight & body composition
37
Glycemic / diabetes
21
Cardiometabolic biomarkers
9
Other clinical outcomes
8
Other (unclassified)
4
Patient-reported / QoL
2

Most-measured metrics

Top 20 metrics across this asset's endpoints

Treatment-emergent AEs (any)Safety/PK

8

Body weight, % changeWeight

8

Body weight, absolute change (kg)Weight

7

AUC₀–∞Safety/PK

7

BMI, changeWeight

5

Plasma concentration (steady state)Safety/PK

5

Fasting glucose, changeGlycemic

5

Waist circumference, changeWeight

5

≥5% weight-loss respondersWeight

4

OSA responderOther clin.

4

HbA1c, changeGlycemic

4

Immunogenicity (ADA)Safety/PK

4

AHI, changeOther clin.

3

CmaxSafety/PK

2

TmaxSafety/PK

2

Half-lifeSafety/PK

2

HbA1c <7.0% achievementGlycemic

2

HOMA-IR (insulin sensitivity)Glycemic

2

≥15% weight-loss respondersWeight

2

C-peptide AUCGlycemic

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

15 of 15

Asset / PopulationKey I/E criterionEvidence
EVOLVE-2A Study of Weekly Oral Ecnoglutide (VRB-101) in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Ecnoglutide (VRB-101)

Obesity / overweight

BMI 27-30Ph 2Active, not recruiting22Jul 2026
NCT07553299A Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Ecnoglutide (VRB-101)

Obesity / overweight

BMI 27-30Ph 2Not yet recruiting17Nov 2026
NCT05184322XW004 To Evaluate the Safety, Tolerability, PK, and PD of Oral Ecnoglutide Tablet in Healthy Adults

Ecnoglutide (XW004)

Healthy volunteers, Obesity / overweight

BMI 22-32Ph 1Completed1Jul 2024
NCT07387094A Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy

Ecnoglutide (XW003)

Obesity / overweight, Sleep apnea

BMI ≥28Ph 3Recruiting1Dec 2027
NCT06335134A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin

Ecnoglutide (XW003)

Healthy volunteers

BMI 20-30Ph 1Completed1Jan 2024
NCT07143227A Study of XW003 Injection in Chinese Adolescents With Obesity

Ecnoglutide (XW003)

Obesity / overweight

BMI 586-2018Ph 1Completed1Apr 2026
NCT05680129A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Dulaglutide in Participants With T2DM

Dulaglutide, Ecnoglutide (XW003)

Type 2 diabetes

BMI 20-35Ph 3Completed1Jul 20241
NCT05813795A Phase 3 Study to Evaluate the Efficacy of XW003 in Adults With Overweight or Obesity

Ecnoglutide (XW003)

Obesity / overweight

BMI 24-28Ph 3Completed1Jun 20241
NCT07434050A Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy

Ecnoglutide (XW003)

Obesity / overweight, Sleep apnea

BMI ≥28Ph 3Recruiting1Jun 2028
NCT07243171A Phase Ib/IIa Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral Ecnoglutide Tablets in Chinese Participants With Overweight or Obesity

Ecnoglutide (XW004)

Obesity / overweight

BMI 24-35Ph 1/2Recruiting1Aug 2026
XW003To Evaluate the Safety, Tolerability, PK, and PD of XW003 Injection in Healthy Adult Participants

Ecnoglutide (XW003)

Healthy volunteers

BMI ≥20Ph 1Completed1Sep 20211
NCT05680155A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Placebo in T2DM Patients

Ecnoglutide (XW003)

Type 2 diabetes

BMI 20-35Ph 3Completed1Jun 20241
NCT05111912Effects of XW003 Versus Liraglutide on Body Weight of Adult Participants With Obesity

Ecnoglutide (XW003), Liraglutide

Obesity / overweight

BMI 30-40Ph 2Completed1Nov 2022
NCT07073417A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)

Ecnoglutide (XW003), Semaglutide

Obesity / overweight

BMI ≥30Ph 2Active, not recruiting1Feb 2027
NCT07628127A Trial of Oral VRB-103 Alone or in Combination With Oral Ecnoglutide (VRB-101) in Participants With Obesity or Overweight

Ecnoglutide

Obesity / overweight

HbA1c ≤6.4%Ph 1Not yet recruiting0Mar 2028