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Latozinemab

4 trials in this asset. Source: ClinicalTrials.gov, as of July 21, 2026.

Trials

4

Ongoing

0

Recruiting

0

Completed

3

Sites

60

Countries

16

Endpoints

43

Composite endpoints

0

Distinct sites and countries across this asset's trials. A site running several of its trials counts once, matching the map. All 43 linked ClinicalTrials.gov endpoints are classified into the categories below. Trial and endpoint linkage does not by itself establish treatment attribution for every endpoint.

Development

Where the program stands

Trials by phase

Phase 1
1
Phase 1/2
1
Phase 2
1
Phase 3
1

Trials by status

Completed
3
Terminated
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
17
Other (unclassified)
14
Fluid / digital biomarkers
5
Global cognition
2
Behavior / neuropsychiatric
2
Other clinical outcomes
2
Neurodegeneration biomarkers
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

Normalized metric codes are available for 2 of 43 classified ClinicalTrials.gov endpoints for this asset; the ranking below covers that coded subset.

Clinical Dementia Rating-Sum of Boxes (CDR-SB)Cognition

1

Neurofilament light (NfL)Neurodeg.

1

Trials

Trials for this asset

Every trial for this asset, with the same search, filters, and sort as the Trials tab.

4 of 4

Alzheimer’s disease and related dementias trials
Asset / Disease areaKey I/E criterionEvidence
NCT04374136A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3)

Latozinemab

Frontotemporal dementia

At-risk or symptomatic FTD · GRN mutation requiredPh 3Terminated44Sep 2025-
NCT03987295A Phase 2 Study to Evaluate Safety of Long-term AL001 Dosing in Frontotemporal Dementia (FTD) Patients (INFRONT-2)

Latozinemab

Frontotemporal dementia

GRN/C9orf72 mutation requiredPh 2Completed12Jun 2024-results
NCT03636204A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (GRN) Mutation

Latozinemab

Frontotemporal dementia

Age 18-80Ph 1Completed8Dec 20191
"MAD"Multiple Ascending Dose Safety, Tolerability, PK Study of AL001 in Alzheimer's Disease Patients & Healthy Adult Subjects

Latozinemab

Alzheimer’s disease

mild-to-moderate ADPh 1/2Completed2Apr 2023-results

Showing 1-4 of 4 trials