GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry

Age 18 years or older Body mass index (BMI) 30 kg/m2 or greater Symptomatic exertional dyspnea, fatigue, or reduced exercise tolerance Left ventricular ejection fraction 50% or greater Probable or established HFpEF per the diagnostic score algorithm (no low-probability result on either the H2FPEF or HFA-PEFF score) Able to perform semi-supine bicycle exercise echocardiography Written informed consent for registry participation and data processing

Significant valvular heart disease Cardiomyopathy other than the typical HFpEF phenotype (suspected amyloidosis, restrictive or hypertrophic cardiomyopathy as the primary problem) Recent acute decompensated heart failure or recent hospitalization for heart failure Unstable coronary artery disease Severe pulmonary disease as the primary cause of dyspnea Severe anemia or another systemic cause of exercise limitation Inability to safely perform an exercise test Very poor echocardiographic window precluding any analysis Active malignancy or gynecological condition that may substantially affect CA-125 (diagnosed endometriosis, pelvic inflammatory disease, suspected ovarian tumor, significant non-cardiac ascites) Absence of consent for registry participation and data processing