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Tilavonemab

6 trials in this asset. Source: ClinicalTrials.gov, as of July 21, 2026.

Trials

6

Ongoing

0

Recruiting

0

Completed

2

Sites

145

Countries

13

Endpoints

159

Composite endpoints

0

Distinct sites and countries across this asset's trials. A site running several of its trials counts once, matching the map. All 159 linked ClinicalTrials.gov endpoints are classified into the categories below. Trial and endpoint linkage does not by itself establish treatment attribution for every endpoint.

Development

Where the program stands

Trials by phase

Phase 1
1
Phase 2
4
Not applicable
1

Trials by status

Completed
2
Terminated
3
Unknown
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Global cognition
64
Behavior / neuropsychiatric
26
Safety / tolerability / PK
23
Neuroimaging
14
Other (unclassified)
14
Function / daily living
12
Other clinical outcomes
4
Caregiver / quality of life
2

Most-measured metrics

Top 20 metrics across this asset's endpoints

Normalized metric codes are available for 40 of 159 classified ClinicalTrials.gov endpoints for this asset; the ranking below covers that coded subset.

ADAS-CogCognition

32

Clinical Dementia Rating-Sum of Boxes (CDR-SB)Cognition

2

ADCS-Activities of Daily Living (ADCS-ADL)Function

2

Mini-Mental State Examination (MMSE)Cognition

2

Neuropsychiatric Inventory (NPI)Behavior

2

Trials

Trials for this asset

Every trial for this asset, with the same search, filters, and sort as the Trials tab.

6 of 6

Alzheimer’s disease and related dementias trials
Asset / Disease areaKey I/E criterionEvidence
NCT02880956A Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Participants With Early Alzheimer's Disease

Tilavonemab

Alzheimer’s disease

Alzheimer's diseasePh 2Completed68Mar 20211results
NCT02985879A Study to Assess Efficacy, Safety, Tolerability, and Pharmacokinetics of ABBV-8E12 in Subjects With Progressive Supranuclear Palsy (PSP)

Tilavonemab

Frontotemporal dementia

Study partner/caregiver requiredPh 2Terminated66Nov 20191results
NCT03712787An Extension Study of ABBV-8E12 in Early Alzheimer's Disease (AD)

Tilavonemab

Alzheimer’s disease

Study partner/caregiver requiredPh 2Terminated57Sep 2021-results
NCT03391765An Extension Study of ABBV-8E12 in Progressive Supranuclear Palsy (PSP)

Tilavonemab

Frontotemporal dementia

Study partner/caregiver requiredPh 2Terminated42Dec 2019-results
NCT03413319Extension Study of ABBV-8E12 in Patients With Progressive Supranuclear Palsy (PSP) Who Completed Study C2N-8E12-WW-104

Tilavonemab

Frontotemporal dementia

Age ≥18Ph 1Completed2Nov 2019-
NCT03744546Expanded Access to ABBV-8E12

Tilavonemab

Frontotemporal dementia

Age ≥40Not applicableUnknown0--

Showing 1-6 of 6 trials