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Oral · GLP-1 agonist

Danuglipron

20 trials in this molecule. Source: ClinicalTrials.gov, as of July 1, 2026.

Trials

20

Active

0

Recruiting

0

Completed

19

Sites

153

Countries

12

Endpoints

402

Composite endpoints

13

Distinct sites and countries across this molecule's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
17
Phase 2
3

Trials by status

Completed
19
Terminated
1

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
287
Weight & body composition
60
Glycemic / diabetes
45
Patient-reported / QoL
9
Cardiometabolic biomarkers
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

AUC₀–∞Safety/PK

38

CmaxSafety/PK

28

Treatment-emergent AEs (any)Safety/PK

23

Body weight, absolute change (kg)Weight

22

HbA1c, changeGlycemic

14

Fasting glucose, changeGlycemic

14

TmaxSafety/PK

9

Half-lifeSafety/PK

7

Body weight, % changeWeight

6

Discontinuation due to AESafety/PK

3

≥5% weight-loss respondersWeight

2

Waist circumference, changeWeight

2

Plasma concentration (steady state)Safety/PK

1

HbA1c <7.0% achievementGlycemic

1

Trials

Programs for this asset

Every trial for this molecule, with the same search, filters, and sort as the Trials tab.

20 of 20

Asset / PopulationKey I/E criterionEvidence
NCT03985293A 16 Week Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults With Type 2 Diabetes Mellitus

Danuglipron

Type 2 diabetes

BMI 24.5-45.4Ph 2Completed83Jun 20211results
NCT04707313A Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults With Obesity

Danuglipron

Obesity / overweight

BMI ≥30Ph 2Completed41Sep 20231results
NCT04617275A 12-WEEK TITRATE STUDY TO EVALUATE SAFETY, TOLERABILITY AND PHARMACODYNAMICS OF PF-06882961 IN ADULTS WITH TYPE 2 DIABETES MELLITUS AND IN NON-DIABETIC ADULTS WITH OBESITY

Danuglipron

Obesity / overweight, Type 2 diabetes

Ph 2Completed38Nov 20211results
NCT035387434-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes

Danuglipron

Type 2 diabetes

HbA1c 7-10.5%Ph 1Completed4May 20191results
NCT04616027STUDY OF PF-06882961 IN PARTICIPANTS WITH TYPE 2 DIABETES MELLITUS WITH VARYING DEGREES OF RENAL IMPAIRMENT AND PARTICIPANTS WITHOUT RENAL IMPAIRMENT

Danuglipron

Healthy volunteers, Renal impairment, Type 2 diabetes

BMI 18-45.4Ph 1Completed3Feb 20221results
NCT06567327A Study to Learn How the Study Medicine Danuglipron is Taken Up Into the Blood and If Danuglipron Changes How the Body Processes Other Study Medicines (Atorvastatin and Rosuvastatin) in Healthy Adults Who Are Overweight or Obese

Danuglipron

Healthy volunteers, Obesity / overweight

BMI 25-45.4Ph 1Completed3Mar 2025
NCT04495140Study To Characterize Mass Balance, Absolute Bioavailability, Fraction Absorbed And Pharmacokinetics Of 14C PF-06882961

Danuglipron

Healthy volunteers

BMI 17.5-30Ph 1Completed2Oct 2020
NCT04604496STUDY OF PF-06882961 IN PARTICIPANTS WITH AND WITHOUT VARYING DEGREES OF HEPATIC IMPAIREMENT

Danuglipron

Healthy volunteers, Hepatic impairment

BMI 17.5-38Ph 1Completed2Jan 2022results
NCT04616339STUDY TO COMPARE PHARMACOKINETICS (PK) OF SINGLE ORAL DOSES OF DIFFERENT PF-06882961 FORMULATIONS IN PARTICIPANTS WHO ARE OVERWEIGHT OR HAVE OBESITY

Danuglipron

Obesity / overweight

BMI 25-40Ph 1Completed1Jul 2021
NCT06541678A Study to Learn if the Study Medicines Called Itraconazole and Cyclosporine Change How the Body Processes the Other Study Medicine Called Danuglipron in Healthy Adults.

Danuglipron

Healthy volunteers

BMI 16-32Ph 1Completed1Mar 2025
NCT06910839Study to Learn About How the Study Medicines Called PF-07976016 and PF-06882961 Are Taken Up by the Body, and if Either of Them Change How the Body Processes the Other Medicine in Otherwise Healthy Adults With Overweight or Obesity

Danuglipron

Obesity / overweight

BMI 25-40Ph 1Terminated1May 2025
NCT04621227Study To Evaluate The Effect Of Two Steady State Doses of PF 06882961 On Rosuvastatin And Midazolam Pharmacokinetics In Otherwise Healthy Adult Participants With Obesity

Danuglipron

Obesity / overweight

BMI ≥30Ph 1Completed1May 2021results
NCT04839393A Drug-Drug Interaction Study Between PF-06882961 and PF-06865571 in Healthy Adult Participants and Overweight Adults or Adults With Obesity Who Are Otherwise Healthy

Danuglipron

Healthy volunteers, Obesity / overweight

Healthy volunteersPh 1Completed1Oct 2021results
NCT03309241First In Human, Single Escalating Oral Dose Study Of PF-06882961 In Healthy Adult Subjects

Danuglipron

Healthy volunteers

BMI 17.5-30.5Ph 1Completed1Feb 2018
NCT03492697A Single Dose Crossover Study In Healthy Subjects To Evaluate Different Formulations Of PF-06882961

Danuglipron

Healthy volunteers

BMI 17.5-30.5Ph 1Completed1Jul 2018
NCT06153758Study to Learn How Different Forms of The Study Medicine Called Danuglipron Are Taken up Into the Blood In Healthy Adults

Danuglipron

Healthy volunteers

BMI 16-32Ph 1Completed1Sep 2024
NCT05093205STUDY TO EVALUATE THE EFFECT OF PF-06882961 ON SINGLE DOSE ATORVASTATIN, MEDAZOLAM AND ORALCONTRACEPTIVE PHARMACOKINETICS IN HEALTHY ADULT PARTICIPANTS

Danuglipron

Healthy volunteers

BMI 20-30Ph 1Completed1Jul 2022results
NCT04889157A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of PF-06882961 in Chinese Adults With Type 2 Diabetes Mellitus

Danuglipron

Type 2 diabetes

BMI 22.5-45.4Ph 1Completed1Feb 2022results
NCT04552470A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06882961 in Japanese Adults With Type 2 Diabetes Mellitus

Danuglipron

Type 2 diabetes

BMI 22.5-45.4Ph 1Completed1Mar 2021results
NCT06568731A Study to Learn How Different Amounts of the Study Medicine Danuglipron Are Taken up Into the Blood in Otherwise Healthy Adults With Overweight or Obesity

Danuglipron

Healthy volunteers, Obesity / overweight

BMI 25-45.4Ph 1Completed1Dec 2024