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Donepezil

136 trials in this asset. Source: ClinicalTrials.gov, as of July 21, 2026.

Trials

136

Ongoing

6

Recruiting

3

Completed

94

Sites

2,348

Countries

42

Endpoints

1,347

Composite endpoints

0

Distinct sites and countries across this asset's trials. A site running several of its trials counts once, matching the map. All 1,347 linked ClinicalTrials.gov endpoints are classified into the categories below. Trial and endpoint linkage does not by itself establish treatment attribution for every endpoint.

Development

Where the program stands

Trials by phase

Early Phase 1
1
Phase 1
24
Phase 1/2
1
Phase 2
33
Phase 2/3
3
Phase 3
20
Phase 4
31
Not applicable
23

Trials by status

Not yet recruiting
2
Recruiting
3
Active, not recruiting
1
Completed
94
Terminated
13
Withdrawn
4
Unknown
19

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Other (unclassified)
346
Safety / tolerability / PK
284
Global cognition
266
Behavior / neuropsychiatric
109
Function / daily living
79
Memory
68
Executive function / language
54
Caregiver / quality of life
43
Other clinical outcomes
41
Neuroimaging
27
Fluid / digital biomarkers
16
Disease progression
5
Amyloid biomarkers
5
Tau biomarkers
2
Neurodegeneration biomarkers
2

Most-measured metrics

Top 20 metrics across this asset's endpoints

Normalized metric codes are available for 313 of 1,347 classified ClinicalTrials.gov endpoints for this asset; the ranking below covers that coded subset.

ADAS-CogCognition

103

Mini-Mental State Examination (MMSE)Cognition

96

Neuropsychiatric Inventory (NPI)Behavior

56

ADCS-Activities of Daily Living (ADCS-ADL)Function

30

Clinical Dementia Rating-Sum of Boxes (CDR-SB)Cognition

19

Montreal Cognitive Assessment (MoCA)Cognition

2

ADAS-CogOther

2

ADAS-CogMemory

2

Phosphorylated tau 217 (p-tau217)Tau

1

Neurofilament light (NfL)Neurodeg.

1

Phosphorylated tau 217 (p-tau217)Amyloid

1

Trials

Trials for this asset

Every trial for this asset, with the same search, filters, and sort as the Trials tab.

136 of 136

Alzheimer’s disease and related dementias trials
Asset / Disease areaKey I/E criterionEvidence
NCT01129596Post-marketing Surveillance of Long-term Administration of Donepezil Hydrochloride -Investigation of the Clinical Condition and Safety in Patients With Alzheimer's Disease-

Donepezil

Alzheimer’s disease

Alzheimer's diseaseNot applicableCompleted722Sep 20151
REFLECT-2Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease

Donepezil, Rosiglitazone

Alzheimer’s disease

mild-to-moderate ADNot applicableCompleted249Jan 20091results
MAyflOwer RoADA Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy

Donepezil, Galantamine, Memantine, Rivastigmine, RO4602522

Alzheimer’s disease

Alzheimer's diseasePh 2Completed142Jun 20151
NCT01251718Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Clinical Safety and Effectiveness in Patients With Alzheimer's Disease

Donepezil

Alzheimer’s disease

Age ≥18Not applicableCompleted106Oct 2015-
NCT00710684A Study of SB-742457, Added to Donepezil for the Treatment of Mild-to-moderate Alzheimer's Disease

Donepezil, Intepirdine

Alzheimer’s disease

mild-to-moderate ADPh 2Completed102May 20101results
NCT00895895Study Comparing 3 Dosage Levels Of SAM-531 In Outpatients With Mild To Moderate Alzheimer Disease

Donepezil, SAM-531

Alzheimer’s disease

Alzheimer's diseasePh 2Terminated96May 2011-results
NCT01266525Effect of Different Doses of SAR110894 on Cognition in Patients With Mild to Moderate Alzheimer's Disease on Donepezil

Donepezil, SAR110894

Alzheimer’s disease

Alzheimer's diseasePh 2Completed82Jan 20132
NCT00708552Study of SB-742457 or Donepezil Versus Placebo in Subjects With Mild-to-moderate Alzheimer's Disease

Donepezil, Intepirdine

Alzheimer’s disease

mild-to-moderate ADPh 2Completed72Mar 20101results
NCT00000173Memory Impairment Study (Mild Cognitive Impairment Study)

Donepezil

Alzheimer’s disease, MCI / preclinical Alzheimer’s

Alzheimer's diseasePh 3Completed72Jan 20049
NCT02580305SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study

Donepezil, Masupirdine, Memantine

Alzheimer’s disease

Alzheimer's diseasePh 2Completed71Nov 20193results
SiroccoProof of Concept Study of Cognitive Improvement in Patients With Alzheimer's Disease

AZD3480, Donepezil

Alzheimer’s disease

Alzheimer's diseasePh 2Completed70Aug 2008-
NCT00165659A Multi-Center, Randomized, Double-Blind, Parallel Group Study With 3 Groups Receiving Placebo, 5 mg of E2020 and 10 mg of E2020

Donepezil

Alzheimer’s disease

Alzheimer's diseasePh 2Completed65May 2005-
NCT02337907BI 409306 in Patients With Cognitive Impairment Due to Alzheimer's Disease.

BI 409306, Donepezil

Alzheimer’s disease

Study partner/caregiver requiredPh 2Completed60Sep 20171results
NCT01278407A Study of E2020 in Patients With Dementia With Lewy Bodies (DLB), Followed by a Long-term Extension Phase

Donepezil

Lewy body dementia

Dementia with Lewy bodiesPh 3Completed56Mar 20132results
NCT00151398Study Evaluating Lecozotan SR in Mild to Moderate Alzheimer's Disease (AD)

Donepezil, Lecozotan

Alzheimer’s disease

Alzheimer's diseasePh 2Completed56Mar 2008-
NCT01539031Compare the Efficacy and Safety of Donepezil Hydrochloride 23 mg Treatment With Continuation of Donepezil Hydrochloride 10 mg Treatment in Japanese Subjects With Severe Alzheimer's Disease

Donepezil

Alzheimer’s disease

Alzheimer's diseasePh 3Completed54Jan 2015-
NCT00630851A Study of the Efficacy and Safety of Aricept in Patients With Severe Alzheimer's Disease Who Are Living in Skilled Nursing Homes

Donepezil

Alzheimer’s disease

Alzheimer's diseasePh 3Completed53Oct 2004-
NCT00543855A Double-blind Study of E2020 (Donepezil Hydrochloride) in Patients With Dementia With Lewy Bodies (DLB) (Study E2020-J081-431)

Donepezil

Lewy body dementia

Dementia with Lewy bodiesPh 2Completed43Feb 2010-results
NCT00096473Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease

Donepezil

Alzheimer’s disease

Age ≥50Ph 3Completed42Jun 2005-
NCT00571064The Effectiveness And Safety Of Donepezil Hydrochloride (E2020) In Subjects With Mild To Severe Alzheimer's Disease Residing In An Assisted Living Facility

Donepezil

Alzheimer’s disease

Alzheimer's diseasePh 4Completed36Dec 2008-results
NCT00230568EARTH 413: A Study of Aricept in Hispanic Patients With Mild to Moderate Alzheimer's Disease (AD)

Donepezil

Alzheimer’s disease

Alzheimer's diseasePh 4Completed35Apr 2007-
NCT00693004Study of PRX-03140 Monotherapy in Subjects With Alzheimer's Disease

Donepezil, PRX-03140

Alzheimer’s disease

Alzheimer's diseasePh 2Terminated33Jan 2010-
NCT01466088Efficacy, Safety, & Tolerability of AZD3480 Patients With Mild to Moderate Dementia of the Alzheimer's Type (AD)

AZD3480, Donepezil

Alzheimer’s disease

Alzheimer's diseasePh 2Completed33May 2014-
NCT01527916Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease

ABT-126, Donepezil

Alzheimer’s disease

mild-to-moderate ADPh 2Completed33Nov 20131
NCT01404169A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease

Donepezil

Alzheimer’s disease

Alzheimer's diseasePh 3Completed32Jul 2014-

Showing 1-25 of 136 trials