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Subcutaneous · GLP-1 agonist

Ecnoglutide (XW003)

10 trials in this program. Source: ClinicalTrials.gov, as of July 1, 2026.

Distinct formulations of the same molecule

This molecule is developed in parallel as separate programs. They are not competing therapies (they share the same active drug) but differ by formulation, route, and developer. Trials below are labeled with their program code.

Trials

10

Active

3

Recruiting

2

Completed

7

Sites

8

Countries

2

Endpoints

98

Composite endpoints

5

Distinct sites and countries across this program's trials. A site running several of its trials counts once, matching the map.

Development

Where the program stands

Trials by phase

Phase 1
3
Phase 2
2
Phase 3
5

Trials by status

Recruiting
2
Active, not recruiting
1
Completed
7

Evidence coverage

What this asset has been measured on

Endpoints grouped into outcome categories, ranked by how often they are measured across this asset's trials.

Safety / tolerability / PK
37
Weight & body composition
25
Glycemic / diabetes
19
Other clinical outcomes
8
Cardiometabolic biomarkers
6
Other (unclassified)
2
Patient-reported / QoL
1

Most-measured metrics

Top 20 metrics across this asset's endpoints

AUC₀–∞Safety/PK

7

Body weight, % changeWeight

6

Plasma concentration (steady state)Safety/PK

5

OSA responderOther clin.

4

Treatment-emergent AEs (any)Safety/PK

4

Body weight, absolute change (kg)Weight

4

HbA1c, changeGlycemic

4

Fasting glucose, changeGlycemic

4

Waist circumference, changeWeight

4

AHI, changeOther clin.

3

BMI, changeWeight

3

≥5% weight-loss respondersWeight

3

Immunogenicity (ADA)Safety/PK

3

CmaxSafety/PK

2

TmaxSafety/PK

2

Half-lifeSafety/PK

2

HbA1c <7.0% achievementGlycemic

2

HOMA-IR (insulin sensitivity)Glycemic

2

≥15% weight-loss respondersWeight

2

C-peptide AUCGlycemic

1

Trials

Trials for XW003

Every trial for this program, with the same search, filters, and sort as the Trials tab.

10 of 10

Asset / PopulationKey I/E criterionEvidence
NCT07387094A Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy

Ecnoglutide (XW003)

Obesity / overweight, Sleep apnea

BMI ≥28Ph 3Recruiting1Dec 2027
NCT06335134A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin

Ecnoglutide (XW003)

Healthy volunteers

BMI 20-30Ph 1Completed1Jan 2024
NCT07143227A Study of XW003 Injection in Chinese Adolescents With Obesity

Ecnoglutide (XW003)

Obesity / overweight

BMI 586-2018Ph 1Completed1Apr 2026
NCT05680129A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Dulaglutide in Participants With T2DM

Dulaglutide, Ecnoglutide (XW003)

Type 2 diabetes

BMI 20-35Ph 3Completed1Jul 20241
NCT05813795A Phase 3 Study to Evaluate the Efficacy of XW003 in Adults With Overweight or Obesity

Ecnoglutide (XW003)

Obesity / overweight

BMI 24-28Ph 3Completed1Jun 20241
NCT07434050A Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy

Ecnoglutide (XW003)

Obesity / overweight, Sleep apnea

BMI ≥28Ph 3Recruiting1Jun 2028
XW003To Evaluate the Safety, Tolerability, PK, and PD of XW003 Injection in Healthy Adult Participants

Ecnoglutide (XW003)

Healthy volunteers

BMI ≥20Ph 1Completed1Sep 20211
NCT05680155A Phase 3 Study to Evaluate the Efficacy of XW003 Compared With Placebo in T2DM Patients

Ecnoglutide (XW003)

Type 2 diabetes

BMI 20-35Ph 3Completed1Jun 20241
NCT05111912Effects of XW003 Versus Liraglutide on Body Weight of Adult Participants With Obesity

Ecnoglutide (XW003), Liraglutide

Obesity / overweight

BMI 30-40Ph 2Completed1Nov 2022
NCT07073417A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)

Ecnoglutide (XW003), Semaglutide

Obesity / overweight

BMI ≥30Ph 2Active, not recruiting1Feb 2027